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DOI: 10.1055/s-0044-1786969
Primary Seminal Vesicle Clear Cell Adenocarcinoma: A Rare Entity
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Abstract
Primary seminal vesicle cancer (SVC) is an exceptionally rare occurrence and is often secondary to bladder or prostate cancers. Adenocarcinoma is being the predominant histological type, with only a few cases reported in the literature.
This case report presents a 54-year-old male diagnosed with primary seminal vesicle clear cell adenocarcinoma who underwent bilateral orchidectomy for bilateral undescended testis 25 years ago. The patient exhibited frequency of urination and imaging studies revealed a large enhancing soft tissue mass in the pelvis, involving the prostate gland, compressing the urinary bladder and left ureter. Biopsy results initially suggested poorly differentiated carcinoma of renal cell origin but subsequent histopathological and immunohistochemical analysis confirmed clear cell adenocarcinoma originating from the seminal vesicles/mesonephric remnants. The patient underwent excision of pelvic mass with sigmoidectomy bladder repair, rectosigmoid anastomosis, and bilateral double-J stenting and followed by adjuvant chemotherapy.
In conclusion, primary SVC is an extremely rare malignancy, and clear cell adenocarcinoma represents a particularly uncommon subtype. This case highlights the importance of considering primary seminal vesicle malignancies when evaluating pelvic masses and the significance of histopathological and immunohistochemical analyses in establishing an accurate diagnosis.
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Publication History
Article published online:
17 September 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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