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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2024; 16(03): 086-091
DOI: 10.1055/s-0044-1786687
Original Article

Impact of Delta Troponin on Short-Term Mortality in Patients with Chronic Renal Dysfunction and NSTEMI

Burak Acem 
1   Department of Emergency Medicine, University of Health Sciences Ümraniye Training and Research Hospital, Istanbul, Türkiye
,
Serkan Emre Eroğlu 
1   Department of Emergency Medicine, University of Health Sciences Ümraniye Training and Research Hospital, Istanbul, Türkiye
,
Serdar Özdemir 
1   Department of Emergency Medicine, University of Health Sciences Ümraniye Training and Research Hospital, Istanbul, Türkiye
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Abstract

Introduction The relationship between mortality and troponin in non-ST-elevation myocardial infarction (NSTEMI) patients with a history of renal failure is quite limited. This study investigated the relationship between blood delta troponin T levels and 30-day mortality in patients with chronic renal dysfunction and NSTEMI.

Materials and Methods This study was conducted prospectively by including patients with chronic renal dysfunction and clinical findings of NSTEMI between February 1, 2021, and August 1, 2022. Demographics, medical history, laboratory parameters, and mortality data were noted. Thirty-day morbidity data was used for mortality. Delta troponin T was calculated using initial and first-hour troponin T values. Patients were grouped as healthy and deceased. Data were evaluated using univariant analysis and receiver operating characteristics analysis.

Results Of the 73 patients included in the study, 29 were female. The mean age of the patients was 67.3 years. The 30-day mortality rate was 9.5%. The sensitivity of the initial troponin T value was 85.7% (42.1–99.6), the specificity was 68.2% (55.6–79.1), and the accuracy was 69.9% (58–80.1), and the sensitivity of the first-hour troponin T value was 85.7% (42.1–99.6), specificity was 75.8% (63.6–85.5), and accuracy was 76.7% (65.4–85.8). The delta troponin T median of the mortality group was 56 (24.2–286.4), and the delta troponin median of the surviving patients was 29.4 (10.7–79.6). The difference was not statistically significant (p = 0.072).

Conclusion The current study's results show that delta troponin T (initial and first hour) is not associated with short-term mortality in patients with chronic renal dysfunction and NSTEMI.

Keywords

myocardial infarction - prognosis - troponin T - kidney failure - renal insufficiency

Authors' Contributions

All authors contributed to collecting the data, writing the article, reviewing, and approving the final article, and they all took responsibility for its contents.


Compliance with Ethical Principles

The study was approved by the ethics committee of the University of Health Sciences Ümraniye Training and Research Hospital (date 02/11/2021; No: B.10.1.TKH.4.34.H.GP.0.01). Informed consent was obtained from all participants who have signed a general consent form allowing anonymous use of data for education, research, and quality improvement.




Publication History

Article published online:
11 July 2024

© 2024. The Libyan Biotechnology Research Center. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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