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DOI: 10.1055/s-0044-1786519
Unusual Metastatic Sites in Malignant Phyllodes Tumor Detected on FDG PET/CT
Abstract
Phyllodes tumor is a rare fibroepithelial neoplasm of the breast. This tumor tends to spread by hematogenous route, with common metastatic sites in the lungs, bones, and liver. Metastases to the pleura, stomach, pancreas, kidneys, and adrenal gland are rare. We present a case of a 52-year-old lady with malignant phyllodes tumor of breast undergone local tumor resection, followed by solitary lung metastasis with lobectomy, and subsequently diagnosed of multiple new metastatic sites in pleura, stomach, pancreas, kidneys, adrenal gland, and bone detected on 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography within 2 years.
Ethical Standards
This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Research Ethics Committee (Kowloon Central/Kowloon East Cluster) of the Hospital Authority, Hong Kong (Reference number: KC/KE-23-0081/ER-3). Informed consent was waived due to the retrospective nature of the study.
Authors' Contributions
L.W.I. designed the study, acquired, and analyzed the data and drafted the manuscript. N.K.K., A.Y.T.K., and K.B.T. critically revised the manuscript for important intellectual content. L.W.I., N.K.K., A.Y.T.K., and K.B.T. had full access to the data, contributed to the study, approved the final version for publication, and took responsibility for its accuracy and integrity.
Publikationsverlauf
Artikel online veröffentlicht:
25. April 2024
© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Reinfuss M, Mituś J, Duda K, Stelmach A, Ryś J, Smolak K. The treatment and prognosis of patients with phyllodes tumor of the breast: an analysis of 170 cases. Cancer 1996; 77 (05) 910-916
- 2 Telli ML, Horst KC, Guardino AE, Dirbas FM, Carlson RW. Phyllodes tumors of the breast: natural history, diagnosis, and treatment. J Natl Compr Canc Netw 2007; 5 (03) 324-330
- 3 Strode M, Khoury T, Mangieri C, Takabe K. Update on the diagnosis and management of malignant phyllodes tumors of the breast. Breast 2017; 33: 91-96
- 4 Zhang Y, Kleer CG. Phyllodes tumor of the breast: histopathologic features, differential diagnosis, and molecular/genetic updates. Arch Pathol Lab Med 2016; 140 (07) 665-671
- 5 Chaney AW, Pollack A, McNeese MD. et al. Primary treatment of cystosarcoma phyllodes of the breast. Cancer 2000; 89 (07) 1502-1511
- 6 National Comprehensive Cancer Network. NCCN Guidelines Version 1.2024 Breast Cancer. Accessed April 13, 2024 at: https://www.nccn.org/professionals/physician_gls/pdf/breast.pdf
- 7 Jacklin RK, Ridgway PF, Ziprin P, Healy V, Hadjiminas D, Darzi A. Optimising preoperative diagnosis in phyllodes tumour of the breast. J Clin Pathol 2006; 59 (05) 454-459
- 8 Singh P, Parida GK, Singhal T, Kumar P, Bishnoi K, Agrawal K. Rare case of phyllodes tumor of breast with cardiac and pancreatic metastases: findings on 18F-FDG PET/CT. J Nucl Med Technol 2023; 51 (02) 156-157
- 9 Yoshidaya F, Hayashi N, Takahashi K. et al. Malignant phyllodes tumor metastasized to the right ventricle: a case report. Surg Case Rep 2015; 1 (01) 121
- 10 Nasri S, Hamila F, Bourigua R, Mestiri S, Elghali MA. Pancreatic metastases and first reported gallbladder metastasis from phyllodes tumor of the breast. Rare Tumors 2020; 12: 2036361320972866
- 11 Choi DI, Chi HS, Lee SH. et al. A rare case of phyllodes tumor metastasis to the stomach presenting as anemia. Cancer Res Treat 2017; 49 (03) 846-849
- 12 Asoglu O, Karanlik H, Barbaros U. et al. Malignant phyllode tumor metastatic to the duodenum. World J Gastroenterol 2006; 12 (10) 1649-1651
- 13 Yuan M, Han B, Zhang N, Lu L, Liu S. Small bowel metastases from malignant phyllodes breast tumor detected by 18 F-FDG PET/CT. Clin Nucl Med 2023; 48 (11) 967-968
- 14 Khanal S, Singh YP, Bhandari A, Sharma R. Malignant phyllodes tumor with metastases to lung, adrenal and brain: a rare case report. Ann Med Surg (Lond) 2018; 36: 113-117
- 15 Karczmarek-Borowska B, Bukala A, Syrek-Kaplita K, Ksiazek M, Filipowska J, Gradalska-Lampart M. A rare case of breast malignant phyllodes tumor with metastases to the kidney: case report. Medicine (Baltimore) 2015; 94 (33) e1312
- 16 Tada Y, Yasunaga M, Tomonobe H. et al. A case of malignant phyllodes tumor of the breast metastasizing to the ovary. Int J Surg Pathol 2022; 30 (04) 427-431