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CC BY-NC-ND 4.0 · Sleep Sci 2024; 17(03): e304-e309
DOI: 10.1055/s-0044-1782166
Short Communication

Is Obstructive Sleep Apnea Associated with Higher Covid-19 Severity?

Autoren

  • Laíla Cândida Zacarias 

    1   Graduate Program in Cardiovascular Sciences, Universidade Federal do Ceará, Fortaleza, CE, Brazil

  • Danielle Mesquita Torres

    2   Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, CE, Brazil

  • Samir Câmara Magalhães

    2   Department of Neurology, Hospital Geral de Fortaleza, Fortaleza, CE, Brazil
    3   Faculty of Medicine, Universidade de Fortaleza, Fortaleza, CE, Brazil

  • Manoel Alves Sobreira-Neto

    4   Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil

  • Camila Ferreira Leite

    1   Graduate Program in Cardiovascular Sciences, Universidade Federal do Ceará, Fortaleza, CE, Brazil
    5   Masters Program in Physiotherapy and Functioning, Universidade Federal do Ceará, Fortaleza, CE, Brazil

Funding Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) - Funding Code 001.
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Abstract

Objective To investigate the associations between obstructive sleep apnea (OSA) and coronavirus disease 2019 (COVID-19) severity.

Methods Twelve individuals hospitalized in a Brazilian tertiary hospital diagnosed with COVID-19 by reverse transcriptase-polymerase chain reaction (RT-PCR) underwent respiratory polygraphy.

Results Polygraphic records identified seven participants without obstructive sleep apnea (OSA) (OSA-) and five with OSA (OSA + ). The OSA+ group presented worse peripheral oxygen saturation (77.6% ± 7.89%) than the OSA- group (84.4% ± 2.57%) (p = 0.041). Additionally, the OSA+ group showed greater COVID-19 severity (100%) than the OSA- group (28.57%) (p = 0.013) and required longer oxygen therapy (p = 0.038), but without difference in the length of hospitalization. The OSA+ group also presented higher rates of platelets (p = 0.008) and D-dimer (1,443 ± 897) than the OSA- group (648 ± 263 ng/mL) (p = 0.019).

Conclusion Obstructive sleep apnea in individuals hospitalized due to COVID-19 was associated with higher COVID-19 severity, worse peripheral oxygen saturation, longer oxygen therapy time, and higher platelet and D-dimer rates.

Keywords

COVID-19 - obstructive sleep apnea - sleep - polygraphy

Authors' Contribution

LCZ: Preparation and planning of work, data acquisition, and manuscript drafting.


DMT: Data acquisition, data analysis, and interpretation.


SCM, MASN: revised the work critically for important intellectual content.


CFL: drafted and made substantial contributions to the conception of the work and revised it critically.




Publikationsverlauf

Eingereicht: 21. Juni 2023

Angenommen: 05. Oktober 2023

Artikel online veröffentlicht:
10. Mai 2024

© 2024. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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