CC BY-NC-ND 4.0 · Endosc Int Open 2018; 06(03): E342-E349
DOI: 10.1055/s-0044-101451
Original article
Owner and Copyright © Georg Thieme Verlag KG 2018

Risk factors for post-colorectal endoscopic submucosal dissection (ESD) coagulation syndrome: a multicenter, prospective, observational study

Jun Arimoto
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan
,
Takuma Higurashi
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan
,
Shingo Kato
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan
,
Akiko Fuyuki
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan
,
Hidenori Ohkubo
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan
,
Takashi Nonaka
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan
,
Yoshikazu Yamaguchi
Department of Anesthesiology and Critical Care, Yokohama City University School of Medicine, Yokohama, Japan
,
Keiichi Ashikari
Department of Gastroenterology, Omori Red Cross Hospital, Tokyo, Japan
,
Hideyuki Chiba
Department of Gastroenterology, Omori Red Cross Hospital, Tokyo, Japan
,
Shungo Goto
Department of Gastroenterology, Hiratsuka City Hospital, Hiratsuka, Japan
,
Masataka Taguri
Department of Biostatistics, Yokohama City University School of Medicine, Yokohama, Japan
,
Takashi Sakaguchi
Department of Gastroenterology, Hiratsuka City Hospital, Hiratsuka, Japan
,
Kazuhiro Atsukawa
Department of Gastroenterology, Hiratsuka City Hospital, Hiratsuka, Japan
,
Atsushi Nakajima
Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan
› Author Affiliations
Further Information

Publication History

submitted 04 September 2017

accepted after revision 22 December 2017

Publication Date:
07 March 2018 (online)

Abstract

Background and study aims Colorectal cancer (CRC) is one of the most common neoplasms and endoscopic submucosal dissection (ESD) is an effective treatment for early-stage CRC. However, it has been observed that patients undergoing ESD often complain of pain, even if ESD has been successfully performed. Risk factors for such pain still remain unknown. The aim of this study was to explore the risk factors for post-colorectal ESD coagulation syndrome (PECS).

Patients and methods This was a prospective multicenter observational trial (UMIN000016781) conducted in 106 of 223 patients who underwent ESD between March 2015 and April 2016. We investigated age, sex, tumor location, ESD operation time, lesion size, duration of hospitalization, and frequency of PECS. We defined PECS as local abdominal pain (evaluated on a visual analogue scale) in the region corresponding to the site of the ESD that occurred within 4 days of the procedure.

Results PECS occurred in 15/106 (14.2 %), and 10 were women (P = 0.01, OR: 7.74 [1.6 – 36.4]), 7 had lesions in the cecum (P < 0.001, OR: 20.6 [3.7 – 115.2]), and 9 in whom ESD operation time was > 90 min (P = 0.002, OR: 10.3 [2.4 – 44.6]). Frequency of deviation from the prescribed clinical path was significantly higher (47 % [7/15] vs. 2 % [2/91], P < 0.001, OR: 38.9 [6.9 – 219.6]), and hospital stay was significantly longer in the PECS group. 

Conclusions Female gender, location of lesion in the cecum, and ESD operation time > 90 minutes were significant risk factors independent of PECS. These findings are important to management of PECS.