Horm Metab Res 2018; 50(04): 271-279
DOI: 10.1055/s-0044-101355
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Maryam Akbari
1  Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
,
Vahidreza Ostadmohammadi
2  Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
,
Kamran B. Lankarani
3  Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
,
Reza Tabrizi
1  Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
,
Fariba Kolahdooz
4  Indigenous and Global Health Research, Department of Medicine, University of Alberta, Edmonton, Canada
,
Seyed Taghi Heydari
5  Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
,
Seyed Habibollah Kavari
6  Faculty member of Rehabilitation Management Department, School of Rehabilitation, University of Social Welfare and Rehabilitation Sciences (USWR),Tehran, Iran
,
Naghmeh Mirhosseini
7  Pure North S’Energy Foundation, Calgary, AB, Canada
,
Alireza Mafi
2  Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
,
Majid Dastorani
2  Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
,
Zatollah Asemi
2  Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
› Author Affiliations
Further Information

Publication History

received 17 December 2017

accepted 10 January 2018

Publication Date:
23 February 2018 (online)

Abstract

The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome (PCOS). Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related randomized-controlled articles (RCTs) published up to November 2017. Two researchers assessed study eligibility, extracted data, and evaluated risk of bias of included RCTs, independently. To check heterogeneity Q-test and I2 statistics were used. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as summary effect size. Seven RCTs were included into our meta-analysis. The findings showed that vitamin D supplementation in women with PCOS significantly decreased high-sensitivity C-reactive protein (hs-CRP) (SMD −1.03; 95% CI, −1.58, −0.49; p <0.001) and malondialdehyde (MDA) (SMD −1.64, 95% CI −2.26 to −1.02, p <0.001), and significantly increased total antioxidant capacity (TAC) levels (SMD 0.86, 95% CI 0.08 to 1.64, p=0.03). Vitamin D supplementation had no significant effect on nitric oxide (NO) (SMD 0.11, 95% CI −0.44 to 0.66, p=0.69) and total glutathione (GSH) levels (SMD 0.54, 95% CI −0.20 to 1.28, p=0.15). Overall, the current meta-analysis demonstrated that vitamin D supplementation to women with PCOS resulted in an improvement in hs-CRP, MDA and TAC, but did not affect NO and GSH levels.