Intra-arterial Peptide Receptor Radionuclide Therapy for the Treatment of Hepatic Neuroendocrine Tumor Metastases: Hope or Hype?

Michael V. Khanjyan; Nicholas Fidelman

doi:10.1055/s-0043-1778658

Seminars in Interventional Radiology, Table of Contents

Semin intervent Radiol 2024; 41(01): 011-015
DOI: 10.1055/s-0043-1778658

Review Article

Intra-arterial Peptide Receptor Radionuclide Therapy for the Treatment of Hepatic Neuroendocrine Tumor Metastases: Hope or Hype?

Authors

Michael V. Khanjyan

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California
Nicholas Fidelman

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California

Abstract

Peptide receptor radionuclide therapy (PRRT) confers significant progression-free survival advantage for patients with small bowel grade 1 and 2 well-differentiated neuroendocrine tumors (WD NET). PRRT may also be clinically beneficial for patients with NET of pancreatic, bronchial, and other sites of origin; patients with paragangliomas; as well as for patients with well-differentiated grade 3 NET. Direct intra-arterial (IA) administration of PRRT into the hepatic artery for patients with NET liver metastases may result in higher radiopharmaceutical dose and longer dwell time in the liver tumors while relatively sparing non-tumor liver tissue and other organs such as the kidneys and bone marrow when compared with intravenous (IV) administration. This review summarizes currently available data on IA and IV PRRT dose distribution, reports safety and efficacy of IA PRRT, and proposes future research questions.

Keywords

interventional radiology - liver cancer - neuroendocrine - peptide receptor radionuclide therapy

Full Text

References

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