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CC BY-NC-ND 4.0 · Indian J Plast Surg 1984; 17(02): 41-45
DOI: 10.1055/s-0043-1778490
Review Article

Augmentation Effect of Certain Vasodilators on Skin Flap Viability—An Experimental Study

V. Bhattacharya
1   Division of Plastic Surgery, Depariment of Surgery, Institute of Medical Sciences, Banaras Hindu Usiversity, Varanasi, India
,
S. K. Bhattacharya
1   Division of Plastic Surgery, Depariment of Surgery, Institute of Medical Sciences, Banaras Hindu Usiversity, Varanasi, India
,
J. M. Das
1   Division of Plastic Surgery, Depariment of Surgery, Institute of Medical Sciences, Banaras Hindu Usiversity, Varanasi, India
,
J. K. Sinha
1   Division of Plastic Surgery, Depariment of Surgery, Institute of Medical Sciences, Banaras Hindu Usiversity, Varanasi, India
,
F. M. Tripathi
1   Division of Plastic Surgery, Depariment of Surgery, Institute of Medical Sciences, Banaras Hindu Usiversity, Varanasi, India
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Summary

The effect of some drugs, inducing vasodilatation, was noted on skin flap survival in rats, 6-hydroxydopamine, which induces chemical sympathectomy, produced marked survival of the flaps. Isoxsuprine and salbutamol, the beta-2 receptor agonists, also induced significant augmentation of flap survival. All these drugs were more cffective than the surgical delay procedure. Reserpine didnot enhance skin flap survival, Since 6-HD, isoxsuprine and salbutamol produce marked vasodilatation, they may prevent skin flap necrosis by enhancing cutaneous blood flow.



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06. März 2024

© 2024. Association of Plastic Surgeons of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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