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CC BY-NC-ND 4.0 · Sleep Sci 2024; 17(02): e194-e198
DOI: 10.1055/s-0043-1777787
Short Communication

Insomnia Polygenic Component on Attention Deficit-Hyperactivity Disorder: Exploring this Association Using Genomic Data from Brazilian Families

Marina Xavier Carpena 
1   Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil
2   Postgraduate Program in Developmental Disorders, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brazil
,
Brenda Barbon Fraga
1   Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil
,
Thais Martins-Silva 
1   Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil
3   Human Development and Violence Research Centre (DOVE), Federal University of Pelotas, Pelotas, RS, Brazil
,
Angélica Salatino-Oliveira
4   Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Júlia Pasqualini Genro
5   Postgraduate Program in Biosciences, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil
,
Guilherme V. Polanczyk
6   Department of Psychiatry, Faculdade de Medicina (FMUSP), Universidade de São Paulo, São Paulo, SP, Brazil
,
Cristian Zeni
7   Health Science Center Houston, University of Texas, Houston, Texas, United States
,
Marcelo Schmitz
8   ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Rodrigo Chazan
9   Postgraduate Program in Psychiatry and Behavioral Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Mara Helena Hutz
4   Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Luis Augusto Rohde 
8   ADHD Outpatient Program, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
10   National Institute of Developmental Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil
,
Luciana Tovo-Rodrigues 
1   Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil
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Abstract

Introduction Insomnia is highly prevalent among individuals with Attention-Deficit/Hyperactivity Disorder (ADHD). However, the biological mechanisms shared between both conditions is still elusive. We aimed to investigate whether insomnia's genomic component is able to predict ADHD in childhood and adolescence.

Methods A Brazilian sample of 259 ADHD probands and their biological parents were included in the study. Their genomic DNA genotypes were used to construct the polygenic risk score for insomnia (Insomnia PRS), using the largest GWAS summary statistics as a discovery sample. The association was tested using logistic regression, under a case-pseudocontrol design.

Results Insomnia PRS was nominally associated with ADHD (OR = 1.228, p = 0.022), showing that the alleles that increase the risk for insomnia also increase the risk for ADHD.

Discussion Our results suggest that genetic factors associated with insomnia may play a role in the ADHD genetic etiology, with both phenotypes likely to have a shared genetic mechanism.

Keywords

polygenic risk score - insomnia - attention-deficit/hyperactivity disorder


Publication History

Received: 15 January 2023

Accepted: 11 September 2023

Article published online:
29 February 2024

© 2024. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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