J Neurol Surg A Cent Eur Neurosurg 2025; 86(01): 017-029
DOI: 10.1055/s-0043-1777761
Original Article

Elevated HSPB1 Expression Is Associated with a Poor Prognosis in Glioblastoma Multiforme Patients

Zhihua Wang
1   Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
,
Zhaohua Fang
2   Department of Neurosurgery, Chongren County People's Hospital, Fuzhou, Jiangxi, China
,
Yongping Gui
3   Department of Neurosurgery, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China
4   Department of Neurosurgery, Xiangya Hospital Jiangxi Hospital, Central South University, Nanchang, Jiangxi, China
,
Bin Xi
3   Department of Neurosurgery, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China
4   Department of Neurosurgery, Xiangya Hospital Jiangxi Hospital, Central South University, Nanchang, Jiangxi, China
,
Zhiping Xie
3   Department of Neurosurgery, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China
4   Department of Neurosurgery, Xiangya Hospital Jiangxi Hospital, Central South University, Nanchang, Jiangxi, China
› Institutsangaben
Funding This research was supported by the Scientific Research initial foundation of Jiangxi Provincial People's Hospital.

Abstract

Background Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer. This study investigated the clinical predictive value of heat shock protein β1 (HSPB1) in patients with GBM.

Methods A correlation was established between HSPB1 expression and GBM progression using data from The Cancer Genome Atlas (TCGA) dataset, Chinese Glioma Genome Atlas dataset, Gene Expression Omnibus dataset, and Human Protein Atlas database. A survival analysis was conducted and an HSPB1-based nomogram was constructed to evaluate the prognostic value of HSPB1 in patients with GBM.

Results Based on TCGA data mining, we discovered that HSPB1 was significantly elevated in patients with GBM and may reflect their response to immunotherapy. In survival analysis, it appeared to have a predictive role in the prognosis of patients with GBM. Five signaling pathways were significantly enriched in the high HSPB1 expression phenotype according to the gene set enrichment analysis. In addition, a significant association was found between HSPB1 expression and immune checkpoints, tumor immune infiltration, tumor immune microenvironment, and immune cell markers in glioma. Overall, our results suggest that HSPB1 may regulate the function of immune cells, serve as a new immunotherapy target, and predict the response to immunotherapy in patients with GBM.

Conclusion HSPB1 appears to serve as a potential predictor of the clinical prognosis and response to immunotherapy in patients with GBM. It may be possible to identify patients who are likely to benefit from immunotherapy by assessing the expression level of HSPB1.

Availability of Data and Material

All data generated or analyzed are included in this article and are available from the corresponding author on reasonable request.


Author Contributions

Z.W. was responsible for the design and concept of the study, analysis and visualization, and writing and revision of the article. Z.F., B.X., and Y.G. contributed to article revising and reviewing. Z.X. contributed to the study design and concept, and article reviewing. All the authors approved the final version of the article.




Publikationsverlauf

Eingereicht: 18. Mai 2023

Angenommen: 24. Oktober 2023

Artikel online veröffentlicht:
03. Juli 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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