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Semin Reprod Med 2023; 41(03/04): 70-79
DOI: 10.1055/s-0043-1777725
Review Article

Obesity and Male Infertility: True, True, and Unrelated?

Carl Ceraolo
1   Department of Urology, University of Rochester, Rochester, New York
,
Amanda Rubano
2   School of Medicine and Dentistry, University of Rochester, Rochester, New York
,
J. Scott Gabrielsen 
1   Department of Urology, University of Rochester, Rochester, New York
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Abstract

While the prevalence of obesity has rapidly increased worldwide, there has also been a notable decline in semen parameters over the last several decades. While obesity can negatively impact reproductive hormones, many studies have sought a link between rising obesity and decreased male fertility potential. Nonetheless, few data support a direct link between the two. The focus on obesity as a causative factor in male infertility can potentially result in patient harm through delayed fertility treatment and missed diagnoses. This review investigates the associations between obesity and male infertility and why a potential direct link has been elusive and may not exist. Additionally, indirect mechanisms that may link the two will be reviewed and treatment options for obese infertile men presenting for evaluation will briefly be discussed.

Keywords

obesity - reproductive hormones - semen analysis - male infertility - GLP-1 receptor agonists


Publication History

Article published online:
10 January 2024

© 2023. Thieme. All rights reserved.

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