Open Access
CC BY 4.0 · Pharmaceutical Fronts 2023; 05(04): e243-e253
DOI: 10.1055/s-0043-1777426
Review Article

The Application of Peroxide for Organic Synthesis in Continuous Flow Chemistry

Rui Zhu
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
,
Yi-Bo Zhou
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
,
Han-Qi Zhou
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
,
Feng-Fan Liu
1   Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
2   Zhejiang Governor Triangle Biomedical Industrial Technology Research Park, Huzhou, People's Republic of China
› Author Affiliations

Funding We are grateful to the Zhejiang Provincial Key R&D Project (Grant No. 2020C03006, 2019-ZJ-JS-03) for financial aid to this work.
Preview

Abstract

Peroxides, as high-efficiency oxidants, are widely used in various areas of industry, such as chemical, pharmaceutical, environmental protection, etc. However, their applications in batches are limited due to their explosive and unstable nature. Continuous flow reactions have the advantages of a large area-to-surface ratio, high mixing efficiency, high mass and heat transfer performance, accurate control of process parameters, and high security. These are beneficial for the improvement of the product yield and the reduction of the reaction time and risk. Thus, in the reaction involving peroxide, continuous flow technology can effectively improve the operational safety and enhance the reaction efficiency of peroxides. This review summarized the applications of peroxides in various organic syntheses in continuous-flow chemistry. These examples illustrated the promising prospects of peroxides in green organic synthesis.



Publication History

Received: 30 July 2023

Accepted: 15 November 2023

Article published online:
08 December 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany