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CC BY-NC-ND 4.0 · Journal of Coloproctology 2023; 43(04): e310-e315
DOI: 10.1055/s-0043-1777057
Review Article

Serrated Polyposis Syndrome: A Literature Review

Authors

  • Guilherme Campos Stephanini

    1   Department of Gastrointestinal Endoscopy, Hospital Sírio Libanês, São Paulo, SP, Brazil

  • Nathan Assis Jordão Pinto

    1   Department of Gastrointestinal Endoscopy, Hospital Sírio Libanês, São Paulo, SP, Brazil

  • Jarbas Faraco

    1   Department of Gastrointestinal Endoscopy, Hospital Sírio Libanês, São Paulo, SP, Brazil

  • Paulo Alberto Falco Pires Correa 

    2   Department of Coloproctology, Hospital Sírio Libanês, São Paulo, SP, Brazil

Fundings None.
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Abstract

Serrated polyposis syndrome is considered the most prevalent colonic polyposis syndrome in the world. Its importance has been increasingly discussed due to the significant increase in the risk of developing colorectal cancer in its affected individuals, similarly to other well-known polyposis syndromes, such as familial adenomatous polyposis.

Serrated lesions of the colon play a major role in this syndrome represented by hyperplastic polyps, serrated sessile lesions and traditional serrated adenomas. Among these lesions, the sessile serrated lesion stands out, considered the main precursor lesion of the serrated pathway of colon carcinogenesis.

Diagnosis of serrated polyposis syndrome is given through colonoscopy examination. Diagnostic criteria are: 1) 5 or more serrated lesions proximal to the rectum, all >4mm in size, with at least two >9mm in size; or 2) 20 serrated lesions of any size located anywhere in the large intestine, with >4 lesions proximal to the rectum.

The ideal treatment is removal of all relevant serrated lesions by colonoscopy. In case of failure of endoscopic therapy, surgery is indicated. This manuscript is based on two case reports and a literature review and aims to broaden the discussion about the subject.

Keywords

colonoscopy - polyphosis - serrated


Publication History

Received: 21 May 2023

Accepted: 24 October 2023

Article published online:
27 November 2023

© 2023. Sociedade Brasileira de Coloproctologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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