Prevalence of Neuropathic Pain in Patients with Osteoarthritis

Abstract

Objective The aim of this study was to determine the prevalence of neuropathic pain and characterize the quality of life of patients with osteoarthritis who consulted a pain clinic in Southwestern Colombia.

Methods A cross-sectional study was conducted via telephone survey. Participants ≥18 years of age with a diagnosis of osteoarthritis were included. The LANSS questionnaire was used to evaluate symptoms and signs of neuropathic pain, and the Short Form-8 was used to evaluate quality of life.

Results Response rate was 54.1% (46/85). The male-to-female ratio was 5:1, with an average age of 72 ± 10 years. Most participants (91.3%) had severe pain. The prevalence of neuropathic pain was 28.3% (95%CI = 15.99-43.46), and the prevalence of neuropathic pain amongst women was 84.6% (95%CI = 54.55-98.01). Dysesthesias and paroxysmal pain were present in 92.3% of individuals with neuropathic pain. Regarding quality of life, limitations in physical activity were the most significant, as 63% of individuals reported such limitations.

Conclusion Neuropathic pain was found to be prevalent and had a negative impact on physical function, highlighting the need for therapeutic strategies targeted to specific neuropathic pain pathways in patients with osteoarthritis.

Keywords

chronic pain - neuralgia - quality of life - osteoarthritis

Work developed at the Department of Physical Medicine and Rehabilitation, Universidad del Valle, Cali, Colombia.

Publication History

Received: 26 December 2022

Accepted: 07 February 2023

Article published online:
08 December 2023

• Referências

• 1 Sen R, Hurley JA. Osteoarthritis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020
• 2 Lane NE, Shidara K, Wise BL. Osteoarthritis year in review 2016: clinical. Osteoarthritis Cartilage 2017; 25 (02) 209-215
• 3 Hunter DJ, Schofield D, Callander E. The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol 2014; 10 (07) 437-441
• 4 Kolasinski SL, Neogi T, Hochberg MC. , et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis care & research (2010). 2020; 72 (02) 149-162
• 5 Hochberg MC, Altman RD, April KT. et al; American College of Rheumatology. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) 2012; 64 (04) 465-474
• 6 Sakuta M. [One hundred books which built up neurology (37)-Charcot JM “Leçons sur les Localsations das les Maladies du Cerveau et de la Moelle Epinière faites a la Faculté de Médecine de Paris”(1876-1880)]. Brain Nerve 2010; 62 (01) 90-91
• 7 McDougall JJ, Linton P. Neurophysiology of arthritis pain. Curr Pain Headache Rep 2012; 16 (06) 485-491
• 8 French HP, Smart KM, Doyle F. Prevalence of neuropathic pain in knee or hip osteoarthritis: A systematic review and meta-analysis. Semin Arthritis Rheum 2017; 47 (01) 1-8
• 9 Pain IAftSo. IASP Terminology. IASP Press. https://www.iasp-pain.org/Education/Content.aspx?ItemNumber=1698#Neuropathicpain . Published 1994 . Updated 14/12/17. [Accessed 05/01, 2021] .
• 10 Thakur M, Dickenson AH, Baron R. Osteoarthritis pain: nociceptive or neuropathic?. Nat Rev Rheumatol 2014; 10 (06) 374-380
• 11 van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain 2014; 155 (04) 654-662
• 12 Colloca L, Ludman T, Bouhassira D. et al. Neuropathic pain. Nat Rev Dis Primers 2017; 3: 17002
• 13 Weingarten TN, Watson JC, Hooten WM. et al. Validation of the S-LANSS in the community setting. Pain 2007; 132 (1-2): 189-194
• 14 López-de-Uralde-Villanueva I, Gil-Martínez A, Candelas-Fernández P, de Andrés-Ares J, Beltrán-Alacreu H, La Touche R. Validity and reliability of the Spanish-language version of the self-administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) pain scale. Neurologia (Engl Ed) 2018; 33 (08) 505-514 (Engl Ed)
• 15 Vallès J, Guilera M, Briones Z, Gomar C, Canet J, Alonso J. ARISCAT Group. Validity of the Spanish 8-item short-form generic health-related quality-of-life questionnaire in surgical patients: a population-based study. Anesthesiology 2010; 112 (05) 1164-1174
• 16 Clasificación estadística internacional de enfermedades y problemas relacionados con la salud: décima revisión (CIE-10), volúmenes 1, 2 y 3 en CD-Rom. Rev Esp Salud Pública 2004; 78: 647-648
• 17 Finnerup NB, Attal N, Haroutounian S. et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015; 14 (02) 162-173
• 18 Hochman JR, Davis AM, Elkayam J, Gagliese L, Hawker GA. Neuropathic pain symptoms on the modified painDETECT correlate with signs of central sensitization in knee osteoarthritis. Osteoarthritis Cartilage 2013; 21 (09) 1236-1242
• 19 Felson DT. An update on the pathogenesis and epidemiology of osteoarthritis. Radiol Clin North Am 2004; 42 (01) 1-9 , v
• 20 Wluka AE, Cicuttini FM, Spector TD. Menopause, oestrogens and arthritis. Maturitas 2000; 35 (03) 183-199
• 21 Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis 2014; 73 (09) 1659-1664
• 22 Reginato AM, Riera H, Vera M. et al; Pan-American League of Associations for Rheumatology (PANLAR) Osteoarthritis Study Group. Osteoarthritis in Latin America: Study of Demographic and Clinical Characteristics in 3040 Patients. J Clin Rheumatol 2015; 21 (08) 391-397
• 23 Charles ST, Carstensen LL. Social and emotional aging. Annu Rev Psychol 2010; 61: 383-409
• 24 Beard JR, Officer A, de Carvalho IA. et al. The World report on ageing and health: a policy framework for healthy ageing. Lancet 2016; 387 (10033): 2145-2154
• 25 Schaible HG. Osteoarthritis pain. Recent advances and controversies. Curr Opin Support Palliat Care 2018; 12 (02) 148-153
• 26 McDougall JJ, Albacete S, Schuelert N. et al. Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain. Osteoarthritis Cartilage 2017; 25 (06) 926-934
• 27 Dimitroulas T, Duarte RV, Behura A, Kitas GD, Raphael JH. Neuropathic pain in osteoarthritis: a review of pathophysiological mechanisms and implications for treatment. Semin Arthritis Rheum 2014; 44 (02) 145-154
• 28 Quartana PJ, Campbell CM, Edwards RR. Pain catastrophizing: a critical review. Expert Rev Neurother 2009; 9 (05) 745-758