Thromb Haemost 2024; 124(04): 281-285
DOI: 10.1055/s-0043-1776394
Invited Clinical Focus

Sex as a Risk Factor for Atrial Fibrillation-Related Stroke

Bernadette Corica
1   Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom
2   Department of Translational and Precision Medicine, Sapienza—University of Rome, Rome, Italy
Trudie Lobban
3   Arrhythmia Alliance, Winchester, United Kingdom
Mellanie True Hills
4, American Foundation for Women's Health, Decatur, TX, United States
Marco Proietti
5   Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
6   Division of Subacute Care, IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy
1   Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom
2   Department of Translational and Precision Medicine, Sapienza—University of Rome, Rome, Italy
› Author Affiliations


Stroke prevention is crucial for the management of patients with atrial fibrillation (AF), and several risk factors have been identified, which increase the risk of AF-related stroke. Among these factors, female sex has been repeatedly associated with AF-related stroke risk; nonetheless, trends toward lower use of oral anticoagulant in women with AF were also reported. In this clinical focus, we discuss about the role of female sex as a risk factor for AF-related stroke, and reflect on the clinical implications of its inclusion among the risk factors for thromboembolic risk stratification in patients with AF.

Publication History

Received: 02 October 2023

Accepted: 04 October 2023

Article published online:
23 October 2023

© 2023. Thieme. All rights reserved.

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