Abstract
A synchronous solid and hematological malignancy is an uncommon condition in which
a patient develops two or more primary cancers, one of which is a solid malignancy
and the other one is a hematological malignancy, within 6 months of primary cancer
diagnosis. The most common histology in solid malignancies is gastrointestinal adenocarcinoma,
which coexists with the lymphoma subtype diffuse large B-cell lymphoma (DLBCL). Here,
we report an extremely rare combination of serous carcinoma of the ovary synchronous
with lymphoma of DLBCL subtype. A woman aged 52 years presented with an abdominal
mass and abdominal pain for a short duration of 15 days. She was evaluated using clinical,
radiological, and biochemical parameters. She was diagnosed with non-Hodgkin lymphoma
by tru-cut biopsy from a bony lytic lesion and ovarian cancer by staging laparotomy.
R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisolone)
chemotherapy for lymphoma and staging laparotomy for persistent adnexal mass resulted
in complete remission of both ovarian cancer and lymphoma. She received paclitaxel
and carboplatin-based postoperative chemotherapy as an adjuvant for ovarian cancer.
Keywords
synchronous multiple primary malignancies - lymphoma - serous ovarian cancer
