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CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2023; 42(03): e256-e258
DOI: 10.1055/s-0043-1775554
Case Report

Is There a Genetic Relationship between Acute Lymphoblastic Leukemia and Meningioma? A Case Report of the Analyses of Three Genes

Há alguma relação genética entre leucemia linfoblástica aguda e meningioma? Relato de caso das análises de três genes

Authors

  • Mehmet Besir Surme 

    1   Department of Neurosurgery, Firat University Hospital, Elazig, Turkey

  • Fatih Demir 

    1   Department of Neurosurgery, Firat University Hospital, Elazig, Turkey

  • Deniz Erol

    2   Department of Genetics, Firat University Hospital, Elazig, Turkey

  • Metin Kaplan

    1   Department of Neurosurgery, Firat University Hospital, Elazig, Turkey
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Abstract

Meningiomas are the most common tumors of the central nervous system, and they are generally slow growing and benign. Acute lymphoblastic leukemia (ALL) is a life-threatening ltype of cancer that involves the accumulation of peripheral blood vessels and immature cells in the bone marrow. Genetic mutations play an important role in the etiology of both diseases. Therefore, in the case herein presented, we investigated the meningioma 1 (MN1), nucleophosmin 1 (NPM1), and Wilms tumor 1 (WT1) genes for possible genetic mutations. A 27-year-old female with a chief complaint of headache and history of lllALL presented with a mass in the left frontal lobe. The pathological analysis revealed a fibroblastic meningioma. However, the three genes were found to be normal in the analysis. In light of these findings, we did not encounter any evidence of a genetic relationship between meningioma and ALL in the present study.

Resumo

Os meningiomas são os tumores mais comuns do sistema nervoso central e geralmente apresentam crescimento lento e são benignos. A leucemia linfoblástica aguda (LLA) é um tipo de câncer com risco de vida que envolve o acúmulo de vasos sanguíneos periféricos e células imaturas na medula óssea. As mutações genéticas desempenham um papel importante na etiologia de ambas as doenças. Portanto, no caso aqui apresentado, investigamos os genes do meningioma 1 (MN1), nucleofosmina 1 (NPM1) e tumor de Wilms 1 (WT1) para possíveis mutações genéticas. Uma mulher de 27 anos com queixa principal de cefaleia e história de LLL apresentou uma massa no lobo frontal esquerdo. A análise anatomopatológica revelou um meningioma fibroblástico. No entanto, os três genes foram considerados normais na análise. À luz desses achados, não encontramos nenhuma evidência de relação genética entre meningioma e LLA no presente estudo.

Keywords

acute lymphoblastic leukemia - meningioma - MN1 - NPM1 - WT1

Palavras-chave

linfoblástico agudo leucemia - MN1 - NPM1 - WT1


Publikationsverlauf

Eingereicht: 11. Dezember 2020

Angenommen: 22. Februar 2021

Artikel online veröffentlicht:
29. September 2023

© 2023. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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