Design and Synthesis of a Novel 1,2,4-Oxadiazole Derivative: 3-(3-(5-((4-Phenylpiperazin-1-yl)methyl)-1,2,4-oxadiazol-3-yl) phenoxy)propan-2-olamines

Deepak Kumar; Ganesh Shinde; Vivek Yadav; Suryakanta Dalai; Mukesh Jangir

doi:10.1055/s-0043-1775446

Synthesis, Table of Contents

Synthesis 2025; 57(09): 1640-1650
DOI: 10.1055/s-0043-1775446

paper

Design and Synthesis of a Novel 1,2,4-Oxadiazole Derivative: 3-(3-(5-((4-Phenylpiperazin-1-yl)methyl)-1,2,4-oxadiazol-3-yl) phenoxy)propan-2-olamines

Authors

Deepak Kumar

^aDepartment of Applied Sciences, Chemistry, NIMS University, Jaipur, India

^bJubilant Biosys Ltd., Greater Noida (UP) 201310, India
Ganesh Shinde

^aDepartment of Applied Sciences, Chemistry, NIMS University, Jaipur, India

^bJubilant Biosys Ltd., Greater Noida (UP) 201310, India
Vivek Yadav

^cDepartment of Pharmaceutical Chemistry, Delhi Pharmaceutical Sciences and Research University, New Delhi, India
Suryakanta Dalai

^bJubilant Biosys Ltd., Greater Noida (UP) 201310, India
Mukesh Jangir∗

^aDepartment of Applied Sciences, Chemistry, NIMS University, Jaipur, India

Abstract

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Abstract

The synthesis of novel heterocyclic 3-(3-(5-((4-phenylpiperazin-1-yl)methyl)-1,2,4-oxadiazol-3-yl)phenoxy)propan-2-olamine derivatives, in particular piperazine and piperidine derivatives of 1,2,4-oxadiazole, is reported. These compounds are a distinguished motif for biological studies. An effective piperazine and piperidine derivative methodology on 1,2,4-oxadiazole substrates has been developed. This pathway, along with good yields and clean reactions, has a broad substrate scope and provides new biologically useful moieties that can be further investigated for their applicability.

Key words

oxadiazoles - alkylation - synthesis - heterocycles - cyclization

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References

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