J Pediatr Infect Dis 2023; 18(06): 310-315
DOI: 10.1055/s-0043-1774781
Original Article

Association between MIS-C and Functional Gastrointestinal Disorders in Children: A Cross-Sectional Study

1   Department of Pediatric Infectious Diseases, Gaziantep University Medicine Faculty, Gaziantep, Türkiye
2   Department of Pediatric Gastroenterology, Adıyaman University Training and Research Hospital, Adıyaman, Türkiye
3   Adıyaman University Faculty of Medicine, Adıyaman, Türkiye
4   Department of Pediatric Infectious Diseases, Adiyaman University Faculty of Medicine, Adiyaman, Türkiye
4   Department of Pediatric Infectious Diseases, Adiyaman University Faculty of Medicine, Adiyaman, Türkiye
› Author Affiliations
Funding None.


Objective Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of coronavirus disease 2019 which causes a hyperinflammatory syndrome that can affect all organ systems. Functional gastrointestinal disorders (FGIDs) are a heterogeneous disease spectrum with unclear etiology. Today, it is known that low-grade inflammation can cause FGIDs. Our aim in this study was to investigate whether there is a higher frequency of FGID in children diagnosed with MIS-C.

Methods In this study, 48 pediatric patients diagnosed with MIS-C were evaluated for functional gastrointestinal diseases according to the Rome IV criteria at least 6 months after diagnosis. The control group consisted of 61 pediatric patients without any chronic disease.

Results In our study, the overall prevalence of FGIDs was 54.1% (n = 26) in the patient group and 22.9% (n = 14) in the control group. The difference between the groups was statistically significant (p < 0.001). The frequencies of undiagnosed abdominal pain, irritable bowel syndrome, constipation, and dyspepsia were 41.6% (n = 20), 12.5% (n = 6), 8.3% (n = 4), and 6.2% (n = 3) in the patient group, respectively. In the control group, the corresponding rates were 9.8% (n = 6), 3.2% (n = 2), 4.9% (n = 3), and 4.9% (n = 3), respectively. A significant difference was observed between the patient and control groups in terms of functional abdominal pain (p < 0.001).

Conclusion The overall frequency of FGIDs and the prevalence of functional abdominal pain were higher in MIS-C patients than in control subjects. The data from this study support the hypothesis that FGIDs are more common in patients diagnosed with MIS-C than in healthy controls.

Ethics Approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Adıyaman University Faculty of Medicine Non-Interventional Clinical Research Ethics Committee.

Consent to Participate

Informed consent was obtained from legal guardians to participate.

Consent for Publication

Informed consent was obtained from legal guardians for publication.

Publication History

Received: 30 March 2023

Accepted: 17 August 2023

Article published online:
22 September 2023

© 2023. Thieme. All rights reserved.

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