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CC BY 4.0 · World J Nucl Med 2023; 22(03): 234-243
DOI: 10.1055/s-0043-1774418
Original Article

3D-OSEM versus FORE + OSEM: Optimal Reconstruction Algorithm for FDG PET with a Short Acquisition Time

Keisuke Tsuda
1   Department of Radiological Technology, Faculty of Health Science, Juntendo University, Tokyo, Japan
2   Division of Functional Imaging, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Japan
,
Takayuki Suzuki
2   Division of Functional Imaging, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Japan
3   Department of Radiology, Tohto Clinic, Tokyo, Japan
,
Kazuhito Toya
4   Department of Radiology, International University of Health and Welfare Mita Hospital, Tokyo, Japan
,
Eisuke Sato
1   Department of Radiological Technology, Faculty of Health Science, Juntendo University, Tokyo, Japan
,
Hirofumi Fujii 
2   Division of Functional Imaging, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Japan
› Author Affiliations
Funding This work was partially supported by a Collaborative Research Grant to the Faculty of Health Science from Juntendo University, Japan.
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Abstract

Objective In this study, we investigated the optimal reconstruction algorithm in fluorodeoxyglucose (FDG) positron emission tomography (PET) with a short acquisition time.

Materials and Methods In the phantom study, six spheres filled with FDG solution (sphere size: 6.23–37 mm; radioactivity ratio of spheres to background = 8:1) and placed in a National Electrical Manufacturers Association phantom were evaluated. Image acquisition time was 15 to 180 seconds, and the obtained image data were reconstructed using each of the Fourier rebinning (FORE) + ordered subsets expectation-maximization (OSEM) and 3D-OSEM algorithms. In the clinical study, mid-abdominal images of 19 patients were evaluated using regions of interest placed on areas of low, intermediate, and high radioactivity. All obtained images were investigated visually, and quantitatively using maximum standardized uptake value (SUV) and coefficient of variation (CV).

Results In the phantom study, FORE + OSEM images with a short acquisition time had large CVs (poor image quality) but comparatively constant maximum SUVs. 3D-OSEM images showed comparatively constant CVs (good image quality) but significantly low maximum SUVs. The results of visual evaluation were well correlated with those of quantitative evaluation. Small spheres were obscured on 3D-OSEM images with short acquisition time, but image quality was not greatly deteriorated. The clinical and phantom studies yielded similar results.

Conclusion FDG PET images with a short acquisition time reconstructed by FORE + OSEM showed poorer image quality than by 3D-OSEM. However, images obtained with a short acquisition time and reconstructed with FORE + OSEM showed clearer FDG uptake and more useful than 3D-OSEM in the light of the detection of lesions.

Keywords

positron emission tomography - short acquisition time - reconstruction - ordered subsets expectation-maximization - Fourier rebinning

Authors' Contribution

Keisuke Tsuda and Hirofumi Fujii were involved in conceptualization, designing, definition of intellectual content, literature search, clinical studies, experimental studies, data acquisition, manuscript preparation, manuscript editing, and manuscript review. Takayuki Suzuki and Kazuhito Toya contributed to designing, definition of intellectual content, clinical studies, experimental studies, manuscript preparation, manuscript editing, and manuscript review. Eisuke Sato helped in designing, definition of intellectual content, data analysis, statistical analysis, manuscript preparation, manuscript editing, and manuscript review. Hirofumi Fujii has provided guarantee for this study.


Note

This paper was presented at the Society of Nuclear Medicine (SNM) 2011 Annual Meeting, San Antonio, Texas, USA, between June 4 and 8, 2011.




Publication History

Article published online:
13 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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