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CC BY 4.0 · World J Nucl Med 2023; 22(03): 226-233
DOI: 10.1055/s-0043-1774417
Original Article

The Prognostic Value of Sequential 18F-FDG PET/CT Metabolic Parameters in Outcomes of Upper-Third Esophageal Squamous Cell Carcinoma Patients Treated with Definitive Chemoradiotherapy

Authors

  • Le Ngoc Ha  ‡   *

    1   Department of Nuclear Medicine, Hospital 108, Hanoi, Vietnam

  • Nguyen Dinh Chau‡   *

    2   Department of Radiation Oncology and Radiosurgery, Hospital 108, Hanoi, Vietnam

  • Bui Quang Bieu

    2   Department of Radiation Oncology and Radiosurgery, Hospital 108, Hanoi, Vietnam

  • Mai Hong Son 

    1   Department of Nuclear Medicine, Hospital 108, Hanoi, Vietnam

Funding No funding.
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Abstract

Objective The aim of this study is to determine prognostic values of sequential 18F-FDG PET/CT metabolic parameters in locally advanced esophageal squamous cell carcinoma (ESCC) patients treated with definitive chemoradiotherapy.

Materials and Methods Forty locally advanced ESCC patients treated with definitive chemoradiotherapy (dCRT) who received pre-treatment 18F-FDG PET/CT (PET1) and 3-months post-treatment 18F-FDG PET/CT (PET2) were enrolled in the prospective study. 18F-FDG PET parameters of the primary tumor including maximum and mean standardized uptake values (SUVmax, SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were calculated on PET delineated primary tumor. Using Kaplan-Meier curves to estimated overall survival (OS), progression-free survival (PFS), and local-regional control (LRC). Cox regression analysis was performed to find significant prognostic factors for survival.

Results With a median follow-up of 13.5 months, the 4-year OS, PFS, and LRC rates were 67.3%, 52.6%, and 53.4% respectively. Patients with MTV 2 > 5.7 had lower OS, PFS, and LRC rates than the lower MTV 2 group (p < 0.05). Univariate Cox regression analysis showed that MTV2 was a significant prognostic factor for OS, PFS, and LRC (p < 0.05).

Conclusion MTV parameter of sequential 18F-FDG PET/CT could be used as a prognostic factor for OS, PFS, and LRC in locally advanced ESCC patients treated with dCRT.

Keywords

18F-FDG PET/CT - sequential metabolic parameter - predictive value - definitive chemoradiotherapy - esophageal squamous cell carcinoma

Authors' Contribution

Le Ngoc Ha, Nguyen Dinh Chau, and Mai Hong Son were involved in writing of the manuscript. Nguyen Dinh Chau helped in data collection. Mai Hong Son, Le Ngoc Ha, and Nguyen Dinh Chau helped in editing and submission of the manuscript. All the authors contributed equally to this paper.


Ethical Approval

This study was approved by the Institutional Review Board of Central Military Hospital 108 (approval No. 165/QD-V108).


Availability of Data and Materials

The data that support the findings of this study are available from the corresponding author upon reasonable request.


* These authors contributed equally to the study and retain the first authorship.


Supplementary Material



Publication History

Article published online:
13 September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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