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CC BY-NC-ND 4.0 · Journal of Gastrointestinal Infections 2023; 13(02): 074-078
DOI: 10.1055/s-0043-1774409
Original Article

Profile of Enteric Fever in Children Admitted to a Tertiary Care Center in North India

Disha Joshi
1   Department of Paediatrics, Dayanand Medical College & Hospital, Ludhiana, Punjab, India
,
Veenu Gupta
2   Department of Microbiology, Dayanand Medical College & Hospital, Ludhiana, Punjab, India
,
Deepak Bhat
1   Department of Paediatrics, Dayanand Medical College & Hospital, Ludhiana, Punjab, India
,
Menal Gupta 
2   Department of Microbiology, Dayanand Medical College & Hospital, Ludhiana, Punjab, India
,
Gurdeep Singh Dhooria
1   Department of Paediatrics, Dayanand Medical College & Hospital, Ludhiana, Punjab, India
› Author Affiliations
Funding None.
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Abstract

Background Enteric fever is a community-acquired systemic infection which is more common in resource-limited overcrowded communities with poor access to sanitation and its management is compounded by the increasing antimicrobial resistance to the first-line antibiotics used.

Materials and Methods This descriptive study reports the clinical profile of children with enteric fever managed at the departments of pediatrics and microbiology of a tertiary care hospital from February 2020 to August 2021. All inpatients who were confirmed (blood culture positive) or probable cases (clinical and serological evidence by Widal test) of enteric fever were included. Profile of all cases and antibiotic sensitivity pattern in culture positive cases were studied.

Results Of the 70 cases enrolled, 40% were females and 60% males, and majority (52.9%) was in the age group of > 5 years. At admission, fever was the most common presentation along with abdominal symptoms. Widal test was positive in 84.6% cases and was found to be 80% sensitive when compared to the gold-standard blood culture. Both Salmonella Typhi (74.3%) and S. Paratyphi (12.9%) isolates were 100% sensitive to azithromycin, cotrimoxazole, and ceftriaxone. Quinolones and second-generation cephalosporin cefuroxime showed high resistance in comparison. None of the isolates was multidrug resistant. All cases were discharged after successful treatment.

Conclusion The burden of disease and antibiotic susceptibility of enteric fever needs to be monitored to guide clinicians in selection of antibiotics.

Keywords

enteric fever - children - Salmonella - blood culture

Ethical Clearance

This article has been approved by institutional ethical committee(IEC).


Author's Contribution

All authors contributed equally to the article.


Data Availability Statement

There is no data associated with this work.




Publication History

Received: 15 May 2023

Accepted: 21 July 2023

Article published online:
12 October 2023

© 2023. Gastroinstestinal Infection Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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