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DOI: 10.1055/s-0043-1772578
Diminished LC3 Expression with Unchanged Beclin 1 Levels in Right Atrial Appendage Tissue of Diabetic Patients Undergoing Coronary Artery Bypass Graft
Funding This study was supported by the Science & Engineering Research Board (SERB), Government of India (grant number: SB/SO/HS-051/2013), granted to Srinivas Gopala; Fellowship from INSPIRE, Department of Science and Technology (IF110342), Government of India, granted to Raji Sasikala Rajendran; and Fellowship from the Council of Scientific and Industrial Research (CSIR; 09/523(0076)/2011-EMR I), Government of India, granted to Nandini Ravikumar Jayakumari.
Abstract
Type 2 diabetes potentiates the risk of heart failure. A vital physiologic process, autophagy, may be impaired in the diabetic heart. The aim of this study was to explore the autophagic status in a human diabetic heart. Techniques like immunohistochemistry and western blotting were employed to examine the expression of some of the important proteins involved in the autophagic machinery. Our brief study reports for the first time evidence of decreased cardiac autophagic levels in diabetic patients.
Publication History
Article published online:
18 December 2023
© 2023. National Academy of Medical Sciences (India). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Unnikrishnan AG, Sahay RK, Phadke U. et al. Cardiovascular risk in newly diagnosed type 2 diabetes patients in India. PLoS One 2022; 17 (03) e0263619
- 2 Xu J, Sun Y, Gong D, Fan Y. Impact of preexisting diabetes mellitus on cardiovascular and all-cause mortality in patients with atrial fibrillation: a meta-analysis. Front Endocrinol (Lausanne) 2022; 13: 921159
- 3 Papatheodorou K, Papanas N, Banach M, Papazoglou D, Edmonds M. Complications of diabetes 2016. J Diabetes Res 2016; 2016: 6989453
- 4 Rajbhandari J, Fernandez CJ, Agarwal M, Yeap BXY, Pappachan JM. Diabetic heart disease: a clinical update. World J Diabetes 2021; 12 (04) 383-406
- 5 Matheus Ade M, Tannus LR, Cobas RA, Palma CC, Negrato CA, Gomes MB. Impact of diabetes on cardiovascular disease: an update. Int J Hypertens 2013; 2013: 653789
- 6 El Hayek MS, Ernande L, Benitah JP, Gomez AM, Pereira L. The role of hyperglycaemia in the development of diabetic cardiomyopathy. Arch Cardiovasc Dis 2021; 114 (11) 748-760
- 7 Wu H, Norton V, Cui K. et al. Diabetes and its cardiovascular complications: comprehensive network and systematic analyses. Front Cardiovasc Med 2022; 9: 841928
- 8 Kanamori H, Takemura G, Goto K. et al. Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes. Autophagy 2015; 11 (07) 1146-1160
- 9 Dewanjee S, Vallamkondu J, Kalra RS, John A, Reddy PH, Kandimalla R. Autophagy in the diabetic heart: a potential pharmacotherapeutic target in diabetic cardiomyopathy. Ageing Res Rev 2021; 68: 101338
- 10 Munasinghe PE, Riu F, Dixit P. et al. Type-2 diabetes increases autophagy in the human heart through promotion of Beclin-1 mediated pathway. Int J Cardiol 2016; 202: 13-20
- 11 Wu Y, Mou X, Sun X. Autophagy may be impelled by collected fatty acids in type 2 diabetic myocardial cells. Int J Cardiol 2017; 229: 3
- 12 Bhansali S, Bhansali A, Walia R, Saikia UN, Dhawan V. Alterations in mitochondrial oxidative stress and mitophagy in subjects with prediabetes and type 2 diabetes mellitus. Front Endocrinol (Lausanne) 2017; 8: 347
- 13 Yu W, Gao B, Li N. et al. Sirt3 deficiency exacerbates diabetic cardiac dysfunction: role of Foxo3A-Parkin-mediated mitophagy. Biochim Biophys Acta Mol Basis Dis 2017; 1863 (08) 1973-1983
- 14 Kanamori H, Naruse G, Yoshida A. et al. Morphological characteristics in diabetic cardiomyopathy associated with autophagy. J Cardiol 2021; 77 (01) 30-40