CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2023; 33(04): 508-513
DOI: 10.1055/s-0043-1772496
Review Article

Pediatric Renovascular Hypertension: A Pediatric Interventional Radiologist's Perspective

Kanav Goyal
1   Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
Taruna Yadav
1   Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
1   Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
Pushpinder Khera
1   Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
1   Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
,
1   Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
› Author Affiliations
Funding None.

Abstract

Renovascular hypertension (RVH) contributes close to one-fourth of the secondary etiologies of hypertension in children and a delay in diagnosis can result in adverse clinical outcomes. RVH in children is clinically silent with elevations in blood pressure measurements sometimes as its sole manifestation. Only a high index of suspicion by the clinician can prompt its detection. Despite the availability of other imaging modalities like ultrasound, computed tomography, and magnetic resonance imaging, digital subtraction angiography is still considered the gold standard to make a diagnosis of RVH. Angioplasty is considered the treatment of choice in appropriately selected patients. In this article, we shall focus on the various imaging findings, and management of RVH in children, which requires a multidisciplinary approach with a special focus on the role of interventional radiology.



Publication History

Article published online:
21 August 2023

© 2023. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Bao W, Threefoot SA, Srinivasan SR, Berenson GS. Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study. Am J Hypertens 1995; 8 (07) 657-665
  • 2 Tullus K. To screen or not to screen: for high blood pressure. Pediatr Nephrol 2018; 33 (01) 81-82
  • 3 Patel PA, Cahill AM. Renovascular hypertension in children. CVIR Endovasc 2021; 4 (01) 10
  • 4 Falkner B, Daniels SR. Summary of the fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Hypertension 2004; 44 (04) 387-388
  • 5 Tullus K, Brennan E, Hamilton G. et al. Renovascular hypertension in children. Lancet 2008; 371 (9622): 1453-1463
  • 6 Lobeck IN, Alhajjat AM, Dupree P. et al. The management of pediatric renovascular hypertension: a single center experience and review of the literature. J Pediatr Surg 2018; 53 (09) 1825-1831
  • 7 Srinivasan A, Krishnamurthy G, Fontalvo-Herazo L. et al. Spectrum of renal findings in pediatric fibromuscular dysplasia and neurofibromatosis type 1. Pediatr Radiol 2011; 41 (03) 308-316
  • 8 Rumman RK, Nickel C, Matsuda-Abedini M. et al. Disease beyond the arch: a systematic review of middle aortic syndrome in childhood. Am J Hypertens 2015; 28 (07) 833-846
  • 9 Trautmann A, Roebuck DJ, McLaren CA, Brennan E, Marks SD, Tullus K. Non-invasive imaging cannot replace formal angiography in the diagnosis of renovascular hypertension. Pediatr Nephrol 2017; 32 (03) 495-502
  • 10 Dillman JR, Smith EA, Coley BD. Ultrasound imaging of renin-mediated hypertension. Pediatr Radiol 2017; 47 (09) 1116-1124
  • 11 Villegas L, Cahill AM, Meyers K. Pediatric renovascular hypertension: manifestations and management. Indian Pediatr 2020; 57 (05) 443-451
  • 12 Krishna A, Kumar O, Singh MK. Renovascular hypertension: a review article. Clin Queries Nephrol 2013; 2: 38-43
  • 13 McLaren CA, Roebuck DJ. Interventional radiology for renovascular hypertension in children. Tech Vasc Interv Radiol 2003; 6 (04) 150-157
  • 14 Goonasekera CD, Shah V, Wade AM, Dillon MJ. The usefulness of renal vein renin studies in hypertensive children: a 25-year experience. Pediatr Nephrol 2002; 17 (11) 943-949
  • 15 Piercy KT, Hundley JC, Stafford JM. et al. Renovascular disease in children and adolescents. J Vasc Surg 2005; 41 (06) 973-982
  • 16 Meyers KE, Cahill AM, Sethna C. Interventions for pediatric renovascular hypertension. Curr Hypertens Rep 2014; 16 (04) 422
  • 17 Louis R, Levy-Erez D, Cahill AM, Meyers KE. Imaging studies in pediatric fibromuscular dysplasia (FMD): a single-center experience. Pediatr Nephrol 2018; 33 (09) 1593-1599
  • 18 Lacombe M. Surgical treatment of renovascular hypertension in children. Eur J Vasc Endovasc Surg 2011; 41 (06) 770-777
  • 19 Agrawal H, Moodie D, Qureshi AM. et al. Interventions in children with renovascular hypertension: a 27-year retrospective single-center experience. Congenit Heart Dis 2018; 13 (03) 349-356
  • 20 Bayrak AH, Numan F, Cantaşdemir M, Baş A. Percutaneous balloon angioplasty of renovascular hypertension in pediatric cases. Acta Chir Belg 2008; 108 (06) 708-714
  • 21 Gardiner Jr GA, Freedman AM, Shlansky-Goldberg R. Percutaneous transluminal angioplasty: delayed response in neurofibromatosis. Radiology 1988; 169 (01) 79-80
  • 22 Kari JA, Roebuck DJ, McLaren CA. et al. Angioplasty for renovascular hypertension in 78 children. Arch Dis Child 2015; 100 (05) 474-478
  • 23 Srinivasan A, Krishnamurthy G, Fontalvo-Herazo L. et al. Angioplasty for renal artery stenosis in pediatric patients: an 11-year retrospective experience. J Vasc Interv Radiol 2010; 21 (11) 1672-1680
  • 24 Towbin RB, Pelchovitz DJ, Cahill AM. et al. Cutting balloon angioplasty in children with resistant renal artery stenosis. J Vasc Interv Radiol 2007; 18 (05) 663-669
  • 25 Shroff R, Roebuck DJ, Gordon I. et al. Angioplasty for renovascular hypertension in children: 20-year experience. Pediatrics 2006; 118 (01) 268-275
  • 26 König K, Gellermann J, Querfeld U, Schneider MB. Treatment of severe renal artery stenosis by percutaneous transluminal renal angioplasty and stent implantation: review of the pediatric experience: apropos of two cases. Pediatr Nephrol 2006; 21 (05) 663-671
  • 27 Eliason JL, Coleman DM, Criado E. et al. Remedial operations for failed endovascular therapy of 32 renal artery stenoses in 24 children. Pediatr Nephrol 2016; 31 (05) 809-817
  • 28 Tullus K, Roebuck DJ, McLaren CA, Marks SD. Imaging in the evaluation of renovascular disease. Pediatr Nephrol 2010; 25 (06) 1049-1056