CC BY 4.0 · Eur J Dent
DOI: 10.1055/s-0043-1772251
Original Article

Comparison of Different Techniques in Post-Extractive Socket Regeneration Using Autologous Tooth Graft: Histological and Clinical Outcomes

Elio Minetti
1   Department of Biomedical, Surgical, Dental Science, University of Milan, Milan, Italy
Andrea Palermo
2   College of Medicine and Dentistry, University of Birmingham, Birmingham, United Kingdom
3   Private Practice, Pescara, Italy
› Author Affiliations
Funding None.


Objective Post-extractive socket grafting techniques reduce alveolar ridge dimensional changes. Numerous graft materials have been suggested and a growing interest in tooth material has been observed as a valuable alternative to synthetic biomaterials or xenografts. Furthermore, different clinical procedures have been proposed for the wound closure of the post-extractive site. This study aims to compare histological and clinical outcomes of two different surgical techniques to seal the post-extractive site with the use of autologous demineralized extracted tooth as graft material.

Materials and Methods Sixteen post-extractive socket without buccal and/or palatal bone walls, in sixteen healthy patients, were grafted with the autologous tooth material treated by the new Tooth Transformer device (Tooth Transformer, Milan, Italy). Alveolar socket preservation procedures were performed without flap elevation. Patients were randomly subdivided into two equal groups according to the site closure technique. In group A, the pedunculate tissue was used, while in group B ice cone technique. A bone samples were collected in each site after 4 months for histological analysis.

Results No significant clinical differences among the different sealing techniques were observed. In both groups, the site was filled by new bone formation after 4 months of healing. The histological analysis revealed 46.1 ± 8.07% of bone volume, 9.2 ± 9.46% of residual graft, and 35.2 ± 12.36% of vital bone in group A, while group B shows 41.22 ± 5.88% of bone volume, 7.94 ± 7.54% of residual graft, and 31.7 ± 7.52% new bone. No statistical differences were detected (p > 0.05).

Conclusion Further studies with a large number of patients, and different observation periods will be needed to confirm the results of this pilot study; however, the interesting data obtained have shown how these techniques, mixed with the autologous dentin derived graft material, seem to promote bone regeneration and reduce physiological bone resorption during alveolar socket preservation treatments.

Ethics Approval Statement

On March 21st, 2019, the University of Chieti Ethics Committee (Italy) authorized the clinical study protocol on a human model registered under the number: 638—21/3/19.

Consent for Publication

The present study was carried out following the principles embodied in the Helsinki Declaration, in its latter form. Patient data were anonymized. Each patient gives a written consent for publication of personal surgical and histological data.

Data Availability Statement

All data and material are available from Prof. Elio Minetti in Milan, Italy.

Authors' Contribution

EM was involved in surgery, data collection, and histologic analysis; AP helped in surgery, data collection, and manuscript preparation; MB contributed to study design and manuscript preparation.

Publication History

Article published online:
20 September 2023

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