Adipositas - Ursachen, Folgeerkrankungen, Therapie 2023; 17(03): 168-169
DOI: 10.1055/s-0043-1771650
Abstracts
Poster

Online searches for SGLT-2 inhibitors and GLP-1 receptor can mirror prescription rates.

P. Berning
1   Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore
2   Department of Medicine, University Hospital Muenster, Muenster
,
O. Dzaye
1   Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore
› Author Affiliations
› Further Information
Also available at
 

Einleitung Several clinical trials have demonstrated that many SGLT-2 inhibitors(SGLT2i) and GLP-1 receptor agonists(GLP-1RA) reduce the risk of cardiovascular events in patients with Type 2 diabetes and atherosclerotic cardiovascular disease. Both drug classes can also improve weight control. Recent reports indicate an underutilization of new cardiometabolic drugs, including SGLT2i and GLP-1RA. We aimed to evaluate the use of online search volumes to reflect United States prescription rates.

Methoden We performed a cross-sectional analysis of Google search volumes and corresponding data from the IQVIA National Prescription Audit(NPA) of pharmacy dispensing of newly prescribed drugs. Monthly data for online searches and prescriptions between January 2016 and December 2021 were collected for selected SGLT2i and GLP-1RA. Prescription data for drug classes (SGLT2i and GLP-1RA) and individual drugs were calculated as the total of queried data for branded drug names. Trends were analyzed for visual and quantitative correlation as well as predictive patterns.

Ergebnisse Overall, online searches increased by 157.6%(95%CI: 142.2–173.1%) and 295.2%(95%CI: 257.7–332.6%) for SGLT2i and GLP-1RA between 2016 and 2021. Prescription rates increased by 114.6%(95%CI: 110.8–118.4%) and 221.0%(95%CI: 212.1–229.9%) for SGLT2i and GLP-1RA for this period. Correlation coefficients (range 0.86–0.99) were strongest for drugs with growing number of prescriptions, for example dapagliflozin, empagliflozin, ertugliflozin, dulaglutide, and semaglutide.

Schlussfolgerung Online searches might represent an additional tool to monitor the utilization trends of cardiometabolic drugs. Associations were strongest for drugs with reported cardioprotective effect. Thus, trends in online searches complement conventionally acquired data to reflect and forecast prescription trends of cardiometabolic drugs.



Publication History

Article published online:
06 September 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany