Adverse Allergic Reaction to Intrathecally Administered Technetium-99m Diethylenetriamine Pentaacetate: A Case Report

Abstract

Intrathecal administration of radiopharmaceuticals is an infrequently performed procedure in most nuclear medicine facilities. It is possible that adverse allergic reactions following the intrathecal administration of radiopharmaceuticals often go unreported. Here we present a case of spontaneous cerebrospinal fluid rhinorrhea with recurrent bacterial meningitis, who underwent radionuclide cisternography for localization of the site of leak and developed an adverse allergic reaction following the intrathecal administration of technetium-99m diethylenetriamine pentaacetate that resolved with appropriate treatment. Imaging, however, could be carried out to our satisfaction and the allergic reaction did not interfere with, or result in discontinuation of the scan procedure.

Keywords

adverse allergic reaction - CSF rhinorrhea - intrathecal route - radionuclide cisternography - ^99mTc DTPA

Authors' Contributions

Ahalya Nair contributed to the conception of the case report; acquisition, analysis, and interpretation of data; and drafting and revision of manuscript, primary responsibility for communication with the journal, peer-review, and publication process. Guneshwaran Poolpandian contributed to the conception of the case report; acquisition, analysis, and interpretation of data; and drafting and revision of manuscript. Kabilash Dhayalan contributed to the conception of the case report; acquisition, analysis, and interpretation of data; and drafting and revision. Jayaram Saibaba contributed to the conception of the case report; acquisition, analysis, and interpretation of data; and drafting and revision.

Ethical Approval

We, the authors, declare that the procedures were followed according to the regulations established by the Clinical Research and Ethics Committee and to the Helsinki Declaration of the World Medical Association. We, the authors, declare having followed the protocols in use at our working center regarding the patient's data publication.

Publication History

Article published online:
06 September 2023

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