CC BY 4.0 · J Neuroanaesth Crit Care 2023; 10(03): 206-208
DOI: 10.1055/s-0043-1771218
Case Report

Anesthetic Management of Transoral Odontoidectomy in a Child with Multiple Drugs Intolerance Syndrome

1   Neuroanesthesia and Critical Care, National Institute for Neurology and Neurosurgery, University College of London NHS Hospital Trust, London, United Kingdom
,
2   Neuroanesthesia and Critical Care Division, Department of Anesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
,
3   Department of Neurosurgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India
› Author Affiliations

Abstract

Patients with an adverse reaction to more than three groups of drugs have multiple drug intolerance syndrome (MDIS). Regional anesthesia can be an attractive alternative when patients presenting for surgery are diagnosed with MDIS for opioids and nonsteroidal anti-inflammatory drugs (NSAIDs). Moreover, supplementary regional anesthetic techniques reduce exposure to multiple anesthetic medications, reducing the incidence of allergic reactions. We report the case of a pediatric patient diagnosed with MDIS presenting for transoral odontoidectomy and tracheostomy, wherein regional anesthesia techniques aided us in providing perioperative analgesia and maintaining hemodynamic stability.



Publication History

Article published online:
23 February 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Behera SK, Das S, Chengappa KG, Xavier AS, Selvarajan S. Multiple drug intolerance syndrome: an underreported distinct clinical entity. Curr Clin Pharmacol 2019; 14 (02) 84-90
  • 2 Pichler WJ, Srinoulprasert Y, Yun J, Hausmann O. Multiple Drug Hypersensitivity. Int Arch Allergy Immunol 2017; 172 (03) 129-138
  • 3 Pani N, Kumar Rath S. Regional & topical anaesthesia of upper airways. Indian J Anaesth 2009; 53 (06) 641-648
  • 4 Kim JS, Ko JS, Bang S, Kim H, Lee SY. Cervical plexus block. Korean J Anesthesiol 2018; 71 (04) 274-288
  • 5 Tsaousi GG, Pourzitaki C, Aloisio S, Bilotta F. Dexmedetomidine as a sedative and analgesic adjuvant in spine surgery: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Pharmacol 2018; 74 (11) 1377-1389
  • 6 Elbadrawi AM, Elkhateeb TM. Transoral approach for odontoidectomy efficacy and safety. HSS J 2017; 13 (03) 276-281
  • 7 Liu W, Guo J, Zheng J, Zheng B, Ruan X. Addition of Dexmedetomidine to Ropivacaine-Induced supraclavicular Block (ADRIB) investigator. Low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia: a randomized controlled trial. BMC Anesthesiol 2022; 22 (01) 249
  • 8 Bao N, Shi K, Wu Y. et al. Dexmedetomidine prolongs the duration of local anesthetics when used as an adjuvant through both perineural and systemic mechanisms: a prospective randomized double-blinded trial. BMC Anesthesiol 2022; 22 (01) 176
  • 9 Kaufman E, Epstein JB, Gorsky M, Jackson DL, Kadari A. Preemptive analgesia and local anesthesia as a supplement to general anesthesia: a review. Anesth Prog 2005; 52 (01) 29-38