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CC BY 4.0 · Eur J Dent 2024; 18(01): 356-359
DOI: 10.1055/s-0043-1771200
Original Article

Evaluation of Mandibular Bone Microstructure in CT Scans of People with Sickle Cell Disease

Viviane de Sousa Moreira Almeida 
1   School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil
,
Mariana Quirino Silveira Soares
2   Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil
,
Patricia Miranda Leite-Ribeiro
1   School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil
,
Izabel Regina Fischer Rubira-Bullen
2   Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil
,
Liliane Elze Falcão Lins-Kusterer
3   Medical School, Federal University of Bahia, Salvador, Bahia, Brazil
,
Viviane Almeida Sarmento
1   School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil
› Institutsangaben
Funding The authors thank the Brazilian Ministry of Health for funding this study.
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Abstract

Objective Sickle cell disease (SCD) is a common inherited disease, and is characterized by a genetic modification that determines the production of a hemoglobin with altered morphology. This anatomical change of hemoglobin leads to vaso-occlusive disorders and premature hemolysis of the cell, causing chronic anemia and bone marrow hyperplasia due to increased hematopoietic demand. As a consequence, several skeletal changes are reported in the skull, spine, ribs, pelvis, femur, and metatarsals. In the craniofacial region, dentofacial deformities are described, especially maxillary protrusion. However, studies evaluating bone microarchitecture are scarce. The aim of this study is to evaluate the mandibular bone microstructure of people with SCD on computed tomography (CT) scans.

Materials and Methods Morphometric parameters were analyzed on CT scans of the mandible of people with SCD and people without this disease or any other disease affecting bone metabolism, matched for sex and age.

Statistical Analysis The results were compared by Student's t-test for paired samples and for an error probability of 5%.

Results This study demonstrated that the mandibular bone of people with SCD presents significantly less number, connectivity and thickness of bone trabeculae, as well as having a lower fractal dimension and greater porosity.

Conclusion Mandibular bone of people with SCD has lower bone density and more widely spaced trabeculae.

Keywords

sickle cell disease - computed tomography - bone changes

Ethical Approval Statement

Research Ethics Committee of the Professor Edgard Santos University Hospital of the Federal University of Bahia. CAAE: 273552190.0000.0049.




Publikationsverlauf

Artikel online veröffentlicht:
20. September 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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