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DOI: 10.1055/s-0043-1771046
Complete Remission of Cutaneous Metastasis from Invasive Breast Cancer with Abemaciclib plus Letrozole
Funding None.
Abstract
Skin metastases from internal malignancies can be the first clinical finding of cancer recurrence. If presentation is delayed, they may ulcerate and develop secondary infection. Through this case, we will highlight a case of breast cancer recurrence with extensive cutaneous metastases that clinically completely responded to oral systemic therapy, thereby obviating the need for chemotherapy and leading to stark improvement in performance status and quality of life.
Patient's Consent
Patient's consent was obtained to use her clinical images and PET scan images during publishing of this Case Report.
Contribution by Authors
Shaunak N. Valame was responsible for identifying the appropriate patient for treatment, counselling of patient, treatment protocols, starting of treatment and follow-ups, and providing the necessary data for compiling the article. Dhruti D. Manek contributed to reviewing the reports, literature search, and manuscript preparation and editing. The manuscript has been read and approved by both the authors.
Publikationsverlauf
Artikel online veröffentlicht:
18. September 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995; 33 (2, Pt 1): 161-182 , quiz 183–186
- 2 Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol 1993; 29 (2, Pt 1): 228-236
- 3 De Giorgi V, Grazzini M, Alfaioli B. et al. Cutaneous manifestations of breast carcinoma. Dermatol Ther 2010; 23 (06) 581-589
- 4 Hussein MR. Skin metastasis: a pathologist's perspective. J Cutan Pathol 2010; 37 (09) e1-e20
- 5 Pipkin CA, Lio PA. Cutaneous manifestations of internal malignancies: an overview. Dermatol Clin 2008; 26 (01) 1-15 , vii
- 6 Alcaraz I, Cerroni L, Rütten A, Kutzner H, Requena L. Cutaneous metastases from internal malignancies: a clinicopathologic and immunohistochemical review. Am J Dermatopathol 2012; 34 (04) 347-393
- 7 Cardoso F, Paluch-Shimon S, Senkus E. et al. 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5). Ann Oncol 2020; 31 (12) 1623-1649
- 8 Roncato R, Angelini J, Pani A. et al. CDK4/6 inhibitors in breast cancer treatment: potential interactions with drug, gene, and pathophysiological conditions. Int J Mol Sci 2020; 21 (17) 6350
- 9 Schoenlaub P, Sarraux A, Grosshans E, Heid E, Cribier B. Survival after cutaneous metastasis: a study of 200 cases. Ann Dermatol Venereol 2001; 128 (12) 1310-1315
- 10 Johnston S, Martin M, Di Leo A. et al. MONARCH 3 final PFS: a randomized study of abemaciclib as initial therapy for advanced breast cancer. NPJ Breast Cancer 2019; 5: 5