CC BY-NC-ND 4.0 · J Neurol Surg Rep 2023; 84(03): e85-e86
DOI: 10.1055/s-0043-1770965
Invited Review

Esthesioneuroblastoma: Management of the N0 neck

Stephanie J. Youssef
1   Department of Otolaryngology-Head and Neck Surgery, Washington University in St Louis, St Louis, Missouri, United States
Nyssa Fox Farrell
1   Department of Otolaryngology-Head and Neck Surgery, Washington University in St Louis, St Louis, Missouri, United States
› Author Affiliations


Esthesioneuroblastoma is a rare sinonasal malignancy that arises from the olfactory epithelium. The overall incidence of lymph node metastases is 25%. However, neck disease can present in a delayed fashion. As such, management of the clinically negative neck is controversial, with some advocating for elective neck treatment and others recommending observation with salvage treatment if necessary. At this time, no prospective head-to-head comparisons of elective versus salvage treatment have been performed.

Publication History

Received: 24 March 2023

Accepted: 12 May 2023

Article published online:
04 August 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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