Subscribe to RSS

DOI: 10.1055/s-0043-1769916
Risk Factors and Outcomes of Occurrence of Anastomotic Leakage and Reoperations for its Management after Colorectal Surgery

Abstract
Background Anastomotic leakage (AL) is still the most annoying postsurgery complication after colorectal resection due to its serious complications up to death. Limited data were available regarding differences in AL incidence, management, and consequences for different types of colorectal resection.
The aim of the present work was to evaluate differences in incidence of AL, incidence of postoperative complications, and length of hospital stay in a large number of patients who underwent elective colorectal resection for management of colorectal lesions. In addition to detect when and what type of reoperation for management of AL occur after colorectal resection.
Patients All 250 included patients underwent elective surgeries for colorectal resection with performance of primary anastomosis for management of colorectal neoplastic and non-neoplastic diseases in the period between May 2016 and July 31, 2021.
We followed the patients for 90 days; we registered the follow-up findings.
Results the rates of AL occurrence were variable after the different procedures. The lowest rate of AL occurrence was found in patients who underwent right hemicolectomy, then in patients who underwent sigmoidectomy, left hemicolectomy, transversectomy and anterior resection (p = 0.004). A stoma was frequently performed during reoperation (79.5%) which was significantly different between different procedures: 65.5% in right hemicolectomy, 75.0% in transversectomy, 85.7% in left hemicolectomy, and 93.0% in sigmoid resection (p < 0.001).
Conclusion Rates, types, time of occurrence and severity of AL vary according to the type of colectomy performed and selective construction of stoma during AL reoperation is currently safely applied with comparable mortality rates for patients who did and who did not have a stoma after reoperation.
Publication History
Received: 17 November 2022
Accepted: 07 March 2023
Article published online:
23 June 2023
© 2023. Sociedade Brasileira de Coloproctologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil
-
References
- 1 Frasson M, Granero-Castro P, Ramos Rodríguez JL. et al; ANACO Study Group. Risk factors for anastomotic leak and postoperative morbidity and mortality after elective right colectomy for cancer: results from a prospective, multicentric study of 1102 patients. Int J Colorectal Dis 2016; 31 (01) 105-114
- 2 Voron T, Bruzzi M, Ragot E. et al. Anastomotic location predicts anastomotic leakage after elective colonic resection for cancer. J Gastrointest Surg 2019; 23 (02) 339-347
- 3 Sparreboom CL, van Groningen JT, Lingsma HF. et al; Dutch ColoRectal Audit group. Different risk factors for early and late colorectal anastomotic leakage in a nationwide audit. Dis Colon Rectum 2018; 61 (11) 1258-1266
- 4 Zarzavadjian Le Bian A, Tabchouri N, Denet C. et al. Anastomotic leakage after laparoscopic colectomy: who will require emergency fecal diversion?. J Laparoendosc Adv Surg Tech A 2021; 31 (09) 1040-1045
- 5 Hyman N, Manchester TL, Osler T, Burns B, Cataldo PA. Anastomotic Leakage and Chronic Presacral Sinus Formation After Low Anterior Resection: Results From a Large Cross-sectional Study. Ann Surg 2007; 245 (02) 254-258
- 6 Sciuto A, Merola G, De Palma GD. et al. Predictive factors for anastomotic leakage after laparoscopic colorectal surgery. World J Gastroenterol 2018; 24 (21) 2247-2260
- 7 Borstlap WAA, Westerduin E, Aukema TS, Bemelman WA, Tanis PJ. Dutch Snapshot Research Group. Anastomotic leakage and chronic presacral sinus formation after low anterior resection. Ann Surg 2017; 266 (05) 870-877
- 8 Veyrie N, Ata T, Muscari F. et al; French Associations for Surgical Research. Anastomotic leakage after elective right versus left colectomy for cancer: prevalence and independent risk factors. J Am Coll Surg 2007; 205 (06) 785-793
- 9 Warps AK, Dekker JWT, Tanis PJ, Tollenaar RAEM. An evaluation of short-term outcomes after reoperations for anastomotic leakage in colon cancer patients. Int J Colorectal Dis 2022; 37 (01) 113-122
- 10 Bakker IS, Grossmann I, Henneman D, Havenga K, Wiggers T. Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit. Br J Surg 2014; 101 (04) 424-432 , discussion 432
- 11 Gallo G, Pata F, Vennix S. et al; 2015 European Society of Coloproctology Collaborating Group. Predictors for anastomotic leak, postoperative complications, and mortality after right colectomy for cancer: results from an international snapshot audit. Dis Colon Rectum 2020; 63 (05) 606-618
- 12 Midura EF, Hanseman D, Davis BR. et al. Risk factors and consequences of anastomotic leak after colectomy: a national analysis. Dis Colon Rectum 2015; 58 (03) 333-338
- 13 Eto K, Urashima M, Kosuge M. et al. Standardization of surgical procedures to reduce risk of anastomotic leakage, reoperation, and surgical site infection in colorectal cancer surgery: a retrospective cohort study of 1189 patients. Int J Colorectal Dis 2018; 33 (06) 755-762
- 14 Kryzauskas M, Bausys A, Degutyte AE. et al. Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery. World J Surg Oncol 2020; 18 (01) 205
- 15 Li YW, Lian P, Huang B. et al. Very early colorectal anastomotic leakage within 5 post-operative days: a more severe subtype needs relaparatomy. Sci Rep 2017; 7: 39936
- 16 Gessler B, Eriksson O, Angenete E. Diagnosis, treatment, and consequences of anastomotic leakage in colorectal surgery. Int J Colorectal Dis 2017; 32 (04) 549-556
- 17 Krarup PM, Jorgensen LN, Harling H. Danish Colorectal Cancer Group. Management of anastomotic leakage in a nationwide cohort of colonic cancer patients. J Am Coll Surg 2014; 218 (05) 940-949
- 18 Bakx R, Busch ORC, Bemelman WA, Veldink GJ, Slors JF, van Lanschot JJ. Morbidity of temporary loop ileostomies. Dig Surg 2004; 21 (04) 277-281
- 19 Ihnát P, Guňková P, Peteja M, Vávra P, Pelikán A, Zonča P. Diverting ileostomy in laparoscopic rectal cancer surgery: high price of protection. Surg Endosc 2016; 30 (11) 4809-4816
- 20 Näsvall P, Dahlstrand U, Löwenmark T, Rutegård J, Gunnarsson U, Strigård K. Quality of life in patients with a permanent stoma after rectal cancer surgery. Qual Life Res 2017; 26 (01) 55-64