Subscribe to RSS

DOI: 10.1055/s-0043-1769583
Mucormycosis of the Middle Ear—A Report of a Rare Case

Abstract
Mucormycosis is an opportunistic fungal infection that often affects the nose and paranasal sinuses. The disease prevalence was very high in India during the coronavirus disease 2019 pandemic, thereby raising public awareness about this disease. The general practitioners were updated about the disease characteristics and the requirement for emergency management. Yet, in some instances, the treatment was inadequate due to delayed presentation and low affordability for treatment. The mucormycosis of the ear, on the other hand, is a rare occurrence that demands meticulous study for early diagnosis and management. Here, we discuss the case of a patient with mucormycosis of the middle ear.
Publication History
Article published online:
19 June 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Kermani W, Bouttay R, Belcadhi M, Zaghouani H, Ben Ali M, Abdelkéfi M. ENT mucormycosis. Report of 4 cases. Eur Ann Otorhinolaryngol Head Neck Dis 2016; 133 (02) 83-86
- 2 Riley TT, Muzny CA, Swiatlo E, Legendre DP. Breaking the mold: a review of mucormycosis and current pharmacological treatment options. Ann Pharmacother 2016; 50 (09) 747-757
- 3 Steinbrink JM, Miceli MH. Mucormycosis. Infect Dis Clin North Am 2021; 35 (02) 435-452
- 4 Biniyam K, Bhat V, Bhandary SB, Aroor R. Asymptomatic mucormycosis of middle ear: an incidental finding during tympanoplasty. Indian J Otol 2014; 20: 83-85
- 5 Hassan MIA, Voigt K. Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors. Med Mycol 2019; 57 (Suppl. 02) S245-S256
- 6 Ibrahim AS, Gebermariam T, Fu Y. et al. The iron chelator deferasirox protects mice from mucormycosis through iron starvation. J Clin Invest 2007; 117 (09) 2649-2657
- 7 Gebremariam T, Liu M, Luo G. et al. CotH3 mediates fungal invasion of host cells during mucormycosis. J Clin Invest 2014; 124 (01) 237-250
- 8 Spreer A, Rüchel R, Reichard U. Characterization of an extracellular subtilisin protease of Rhizopus microsporus and evidence for its expression during invasive rhinoorbital mycosis. Med Mycol 2006; 44 (08) 723-731
- 9 Patiño-Medina JA, Maldonado-Herrera G, Pérez-Arques C. et al. Control of morphology and virulence by ADP-ribosylation factors (Arf) in Mucor circinelloides. Curr Genet 2018; 64 (04) 853-869
- 10 Bhansali A, Bhadada S, Sharma A. et al. Presentation and outcome of rhino-orbital-cerebral mucormycosis in patients with diabetes. Postgrad Med J 2004; 80 (949): 670-674
- 11 Charfi S, Ayadi L, Makni S. et al. Rhinocerebral mucormycosis: anatomoclinical study of seventh cases. J Mycol Med 2008; 18: 46-52
- 12 Spellberg B, Edwards Jr J, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev 2005; 18 (03) 556-569
- 13 Rogers TR. Treatment of zygomycosis: current and new options. J Antimicrob Chemother 2008; 61 (Suppl. 01) i35-i40
- 14 Kim JG, Park HJ, Park JH. et al. Importance of immediate surgical intervention and antifungal treatment for rhinocerebral mucormycosis: a case report. J Korean Assoc Oral Maxillofac Surg 2013; 39 (05) 246-250
- 15 Almannai M, Imran H, Estrada B, Siddiqui AH. Successful treatment of rhino-orbital mucormycosis with posaconazole and hyperbaric oxygen therapy. Pediatr Hematol Oncol 2013; 30 (03) 184-186
- 16 Yun MW, Lui CC, Chen WJ. Facial paralysis secondary to tympanic mucormycosis: case report. Am J Otol 1994; 15 (03) 413-414
- 17 Macdonell RA, Donnan GA, Kalnins RM, Richards MJ, Bladin PF. Otocerebral mucormycosis–a case report. Clin Exp Neurol 1987; 23: 225-232
- 18 Hazarika P, Ravikumar V, Nayak RG, Roa PS, Shivnanda PG. Rhinocerebral mucormycosis. Ear Nose Throat J 1984; 63: 100-106