J Pediatr Infect Dis 2023; 18(05): 240-244
DOI: 10.1055/s-0043-1769121
Original Article

Evaluation of Ocular Findings Following Multisystem Inflammatory Syndrome in Children

1   Division of Paediatric Infectious Diseases, Health Sciences University Tepecik Training and Research Hospital, Izmir, Türkiye
Emine Kaya-Guner
2   Department of Ophthalmology, Health Sciences University Tepecik Training and Research Hospital, Izmir, Türkiye
Yıldız Ekemen-Keles
1   Division of Paediatric Infectious Diseases, Health Sciences University Tepecik Training and Research Hospital, Izmir, Türkiye
Eda Karadag-Oncel
1   Division of Paediatric Infectious Diseases, Health Sciences University Tepecik Training and Research Hospital, Izmir, Türkiye
Ahu Kara-Aksay
1   Division of Paediatric Infectious Diseases, Health Sciences University Tepecik Training and Research Hospital, Izmir, Türkiye
Dilek Yilmaz
1   Division of Paediatric Infectious Diseases, Health Sciences University Tepecik Training and Research Hospital, Izmir, Türkiye
3   Division of Paediatric Infectious Diseases, Department of Paediatrics, Izmir Katip Celebi University Faculty of Medicine, Izmir, Türkiye
› Author Affiliations


Objective Multisystem inflammatory syndrome (MIS-C) in children is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and can be mortal with the involvement of multiple organ systems. However, long-term effects on all organs and organ systems involvement are still unclear or even whether this condition may still occur in which organs. This report aims to identify ocular findings in children with MIS-C on the follow-up.

Methods This is a prospective cross-sectional study. Cases diagnosed with MIS-C between May 2020 and February 2021 in our hospital (e.g., cases aged 1 month–18 years old) were included in the study. The same ophthalmologist followed up with the patients after discharge. Patients underwent detailed ophthalmic examinations, including slit lamp biomicroscopy and fundoscopy, best-corrected visual acuity, and Schirmer's 2 test.

Results Our study included 22 patients treated with the MIS-C. Twelve (54.5%) were girls, and 10 (45.5%) were boys. Their mean age was 8.7 ± 4.9 years. Pathological ocular findings were found in six (27.2%) patients in the follow-up. The most common finding was punctate epitheliopathy in four (18.2%) patients. The cause of punctate epitheliopathy was dry eye. All patients recovered with treatment.

Conclusion Our study is the first to evaluate ocular findings in MIS-C in the long term. Regardless of the severity of the disease, the most common ocular finding in our study was punctate epitheliopathy, that is, dry eye. According to our results, we think patients should be followed up on pathological ocular findings after discharge.

Publication History

Received: 18 January 2023

Accepted: 19 April 2023

Article published online:
23 May 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

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