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CC BY-NC-ND 4.0 · Ann Natl Acad Med Sci 2023; 59(03): 170-173
DOI: 10.1055/s-0043-1768979
Brief Report

Cathelicidin Antimicrobial Peptide (CAMP) and Its Correlation with Serum 25 Hydroxy Vitamin D in Under-Five Children with Pneumonia

Aashima Dabas
1   Department of Pediatrics, Maulana Azad Medical College, New Delhi, India
,
Nisha Kukreti
2   Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
,
Dheeraj Shah
2   Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
,
Pooja Dewan
2   Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
,
Ajay Kumar Bansal
3   Department of Biostatistics and Medical Informatics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
,
Piyush Gupta
2   Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
› Author Affiliations Funding Grant awarded to Principal Investigator Dr Piyush Gupta by Indian Council of Medical Research.
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Abstract

Cathelicidins are human peptides involved in innate immunity, and are believed to be mediators of vitamin D-related immune benefits. We aimed to evaluate the correlation between serum levels of 25 hydroxy vitamin D (25(OH)D) and serum cathelicidin antimicrobial peptide (CAMP) in children hospitalized with severe pneumonia. This was a secondary analysis from a larger randomized double-blind placebo-controlled trial on vitamin D supplementation in severe pneumonia. Children aged 6 months to 5 years with the World Health Organization (WHO) defined severe pneumonia were included. Any child with rickets, immunodeficiency, or chronic illness was excluded. Baseline serum CAMP, serum 25(OH)D, and immunoglobulins were measured and analyzed. A total of 163 under-five children were recruited with mean (standard deviation) age 16.4 (13.0) months. The median (interquartile range [IQR]) serum CAMP was 12.5(8.0–20.0) ng/mL and serum 25(OH)D was 14.4 (8.4–24.2) ng/mL. There was no significant correlation between serum cathelicidin and serum 25(OH)D (r = −0.064, p = 0.415). Serum 25(OH)D was low (<20 ng/mL) in 105(64.4%) participants. Median (IQR) serum CAMP was comparable between children with low (<20 ng/mL) and normal serum 25(OH)D levels (13.0 [8.2, 22.1] and 12.0 [8.0, 17.4] pg/mL; p = 0.2). Serum cathelicidin showed significant positive correlation with serum immunoglobulin M levels (r= 0.456, p < 0.001). There was no significant correlation between serum cathelicidin and serum vitamin D in under-five children hospitalized with severe pneumonia.

Keywords

cathelicidin - vitamin D - infection - children - pediatric

Any Previous Presentation of the Manuscript

We declare that manuscript has not been previously published nor is not being considered for publication elsewhere.


Authors' Contribution

PG, DS, PD, and AKB contributed to study design and conceptualization. AD and NK were involved in data acquisition and analysis. Initial draft was written by AD and NK. The manuscript was revised with critical inputs from DS, PD, AKB, and PG. All authors have read and approve the final content of the manuscript.




Publication History

Article published online:
13 July 2023

© 2023. National Academy of Medical Sciences (India). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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