RSS-Feed abonnieren
PDF herunterladen
DOI: 10.1055/s-0043-1768958
Molecular Screening for Urothelial Cancer: How Close We Are?
Abstract
Early detection of urothelial cancer offers the potential for effective and successful treatment. Despite previous efforts, currently, there is not a well-validated, recommended screening program in any country. This integrative, literature-based review provides details on how recent molecular advances may further advance early tumor detection. The minimally invasive liquid biopsy is capable of identifying tumor material in human fluid samples from asymptomatic individuals. Circulating tumor biomarkers (cfDNA, exosomes, etc.) are very promising and are attracting the interest of numerous studies for the diagnosis of early-stage cancer. However, this approach definitely needs to be refined before clinical implementation. Nevertheless, despite the variety of current obstacles that require further research, the prospect of identifying urothelial carcinoma by a single urine or blood test seems truly intriguing.
Publikationsverlauf
Artikel online veröffentlicht:
23. Mai 2023
© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
References
- 1 Menyhárt O, Fekete JT, Győrffy B. Demographic shift disproportionately increases cancer burden in an aging nation: current and expected incidence and mortality in Hungary up to 2030. Clin Epidemiol 2018; 10: 1093-1108
- 2 Coleman MP, Forman D, Bryant H. et al; ICBP Module 1 Working Group. Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995-2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data. Lancet 2011; 377 (9760): 127-138
- 3 Loud JT, Murphy J. Cancer screening and early detection in the 21st century. Semin Oncol Nurs 2017; 33 (02) 121-128
- 4 Zavon MR. Principles and practice of screening for disease. JAMA 1969; 123: 3
- 5 Lobo N, Afferi L, Moschini M. et al. Epidemiology, screening, and prevention of bladder cancer. Eur Urol Oncol 2022; 5 (06) 628-639
- 6 Kamat AM, Karam JA, Grossman HB, Kader AK, Munsell M, Dinney CP. Prospective trial to identify optimal bladder cancer surveillance protocol: reducing costs while maximizing sensitivity. BJU Int 2011; 108 (07) 1119-1123
- 7 Leiblich A. Recent developments in the search for urinary biomarkers in bladder cancer. Curr Urol Rep 2017; 18 (12) 100
- 8 Batista R, Vinagre N, Meireles S. et al. Biomarkers for bladder cancer diagnosis and surveillance: a comprehensive review. Diagnostics (Basel) 2020; 10 (01) 10
- 9 Akhtar M, Al-Bozom IA, Ben Gashir M, Taha NM, Rashid S, Al-Nabet ADMH. Urothelial carcinoma in situ (CIS): new insights. Adv Anat Pathol 2019; 26 (05) 313-319
- 10 Vickers AJ, Bennette C, Kibel AS. et al. Who should be included in a clinical trial of screening for bladder cancer?: a decision analysis of data from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Cancer 2013; 119 (01) 143-149
- 11 Messing EM, Madeb R, Young T. et al. Long-term outcome of hematuria home screening for bladder cancer in men. Cancer 2006; 107 (09) 2173-2179
- 12 Starke N, Singla N, Haddad A, Lotan Y. Long-term outcomes in a high-risk bladder cancer screening cohort. BJU Int 2016; 117 (04) 611-617
- 13 Barata PC, Koshkin VS, Funchain P. et al. Next-generation sequencing (NGS) of cell-free circulating tumor DNA and tumor tissue in patients with advanced urothelial cancer: a pilot assessment of concordance. Ann Oncol 2017; 28 (10) 2458-2463
- 14 Robertson AG, Kim J, Al-Ahmadie H. et al; TCGA Research Network. Comprehensive molecular characterization of muscle-invasive bladder cancer. Cell 2017; 171 (03) 540-556.e25
- 15 Audenet F, Attalla K, Sfakianos JP. The evolution of bladder cancer genomics: what have we learned and how can we use it?. Urol Oncol 2018; 36 (07) 313-320
- 16 Mitra AP. Molecular substratification of bladder cancer: moving towards individualized patient management. Ther Adv Urol 2016; 8 (03) 215-233
- 17 Porten SP. Epigenetic alterations in bladder cancer. Curr Urol Rep 2018; 19 (12) 102
- 18 Pop-Bica C, Gulei D, Cojocneanu-Petric R, Braicu C, Petrut B, Berindan-Neagoe I. Understanding the role of non-coding RNAs in bladder cancer: from dark matter to valuable therapeutic targets. Int J Mol Sci 2017; 18 (07) 7
- 19 Advancing cancer screening with liquid biopsies. Cancer Discov 2018; 8 (03) 256
- 20 Aravanis AM, Lee M, Klausner RD. Next-generation sequencing of circulating tumor DNA for Early Cancer Detection. Cell 2017; 168 (04) 571-574
- 21 Calabuig-Fariñas S, Jantus-Lewintre E, Herreros-Pomares A, Camps C. Circulating tumor cells versus circulating tumor DNA in lung cancer-which one will win?. Transl Lung Cancer Res 2016; 5 (05) 466-482
- 22 Tanos R, Thierry AR. Clinical relevance of liquid biopsy for cancer screening. Transl Cancer Res 2018; •••: 7
- 23 Yu J, Sadakari Y, Shindo K. et al. Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms. Gut 2017; 66 (09) 1677-1687
- 24 Green EA, Li R, Albiges L. et al. Clinical utility of cell-free and circulating tumor DNA in kidney and bladder cancer: a critical review of current literature. Eur Urol Oncol 2021; 4 (06) 893-903
- 25 Ward DG, Baxter L, Gordon NS. et al. Multiplex PCR and next generation sequencing for the non-invasive detection of bladder cancer. PLoS One 2016; 11 (02) e0149756
- 26 Cohen JD, Li L, Wang Y. et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 2018; 359 (6378): 926-930
- 27 Yang S, Che SP, Kurywchak P. et al. Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer. Cancer Biol Ther 2017; 18 (03) 158-165
- 28 Belotti Y, Lim CT. Microfluidics for liquid biopsies: recent advances, current challenges, and future directions. Anal Chem 2021; 93 (11) 4727-4738
- 29 Bardelli A, Pantel K. Liquid biopsies, what we do not know (yet). Cancer Cell 2017; 31 (02) 172-179
- 30 Printz C. Liquid biopsies offer promise and challenges: the science of liquid biopsies is advancing rapidly, but more testing and validation are needed before widespread use. Cancer 2018; 124 (11) 2269-2270
- 31 Aravanis AM, Lee M, Klausner RD. Next-generation sequencing of circulating tumor DNA for early cancer detection. Cell 2017; 168 (04) 571-574