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CC BY-NC-ND 4.0 · J Lab Physicians 2023; 15(04): 616-620
DOI: 10.1055/s-0043-1768635
Brief Report

Profile of Cutaneous Bacterial Flora in Pemphigus Patients

Srujana Mohanty 
1   Department of Microbiology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India
,
Swarnatrisha Saha
1   Department of Microbiology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India
,
Shehnaz Firdaus
1   Department of Microbiology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India
,
Chandra Sekhar Sirka
2   Department of Dermatology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India
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Funding None.
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Abstract

Objectives Pemphigus, a group of autoimmune bullous diseases, can be fatal, resulting from overwhelming opportunistic infection of lesions secondary to cutaneous bacterial infections. This study aimed to look into the cutaneous bacterial infection profile of pemphigus patients as timely identification and appropriate treatment can play a major role in reducing mortality.

Materials and Methods Pus samples/swabs received from patients with pemphigus over a 2-year period from July 2018 to June 2020 were subjected to standard microbiological culture techniques and susceptibility testing. The frequency of isolation and susceptibility profile of the different bacterial pathogens toward various antimicrobial agents were interpreted and analyzed as per the Clinical and Laboratory Standards Institute's guidelines.

Results Samples from 315 patients were received during the study period comprising of 203 (64.4%) males and 112 (35.5%) females. Of 211 samples which were culture-positive, a total of 245 bacterial isolates were obtained, comprising of 158 Gram-positive cocci and 87 Gram-negative bacilli. Staphylococcus aureus (138, 56.3%) was the most common isolate followed by Pseudomonas aeruginosa (41, 16.7%) and Escherichia coli (16, 6.5%). Methicillin resistance was observed in 24.6% Staphylococcus aureus isolates and carbapenem resistance in 9.5 to 14.6% Gram-negative bacilli.

Conclusions Study findings emphasize the need for continuous monitoring of cutaneous pemphigus lesions for appropriate choice of antimicrobial therapy.

Keywords

methicillin-resistant S. aureus - MRSA - pemphigus - Staphylococcus aureus - susceptibility

Ethics Approval

The study obtained review exemption by the Institutional Ethics Committee (IEC) of our Institute, i.e., the Institutional Ethics Committee of All India Institute of Medical Sciences, Bhubaneswar, Odisha, India. Reference number - T/IM-NF/Micro/20/123 dated 24.09.2020.


Authors' Contributions

• S.M. - provided substantial contribution to the concept and design of the study, acquisition, analysis, and interpretation of data for the work, did the literature search, and revised the work for important intellectual content. She is the corresponding author who gave the final approval for the manuscript to be published.


• S.S. - provided substantial contribution to the acquisition, analysis, and interpretation of data for the work, did the literature search, and drafted the initial manuscript.


• S.F. - provided substantial contribution to the acquisition, analysis, and interpretation of data for the work, did the literature search, and revised the work for important intellectual content.


• C.S.S. – was the treating physician and contributed to the acquisition, analysis, and interpretation of data for the study as well as critically revised the work for important intellectual content.


Note

Department and institution to which work should be credited-Department of Microbiology and Dermatology, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India.




Publikationsverlauf

Eingereicht: 01. Februar 2023

Angenommen: 29. März 2023

Artikel online veröffentlicht:
05. Mai 2023

© 2023. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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