CC BY-NC-ND 4.0 · Asian J Neurosurg 2023; 18(02): 366-371
DOI: 10.1055/s-0043-1768603
Case Report

Mature Teratoma with Somatic-Type Malignancy: An Entity of Unacquaintance—A Case Report

Batuk Diyora
1   Department of Neurosurgery, LTMG Hospital, Mumbai, Maharashtra, India
Kavin Devani
1   Department of Neurosurgery, LTMG Hospital, Mumbai, Maharashtra, India
Sridhar Epari
2   Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, Tata Memorial Hospital and ACTREC, Mumbai, Maharashtra, India
Gauri Deshpande
2   Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, Tata Memorial Hospital and ACTREC, Mumbai, Maharashtra, India
Anup Purandare
1   Department of Neurosurgery, LTMG Hospital, Mumbai, Maharashtra, India
Ravi Wankhade
1   Department of Neurosurgery, LTMG Hospital, Mumbai, Maharashtra, India
› Author Affiliations


Primary intracranial teratomas are nongerminomatous germ cell tumors. They are infrequent lesions along the craniospinal axis, with their malignant transformation extremely uncommon. A 50-year-old-male patient presented with one episode of generalized tonic–clonic seizure (GTCS), without any neurological deficit. Radiological imaging revealed a large lesion in the pineal region. He underwent gross total excision of the lesion. Histopathological examination was representative of teratoma with adenocarcinomatous malignant transformation. He underwent adjuvant radiation therapy and had an excellent clinical outcome. The present case highlights the rarity of malignant transformation of the primary intracranial mature teratoma.

Informed Consent

Patient's informed consent was obtained for this study.

Publication History

Article published online:
07 June 2023

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