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Homeopathy 2024; 113(01): 025-031
DOI: 10.1055/s-0043-1768465
Original Research Article

Impact of a Novel Homeopathic Complex Medicine on the Management of Multiple Antibiotic-Resistant Bovine Mastitis: An Open-Label, Non-Randomized, Placebo-Controlled Trial

Bruna de Fatima Antunes Laginestra 
1   Paranaense University—Praça Mascarenhas de Moraes, Umuarama, Paraná, Brazil
,
Thaís Camaso de Sá 
1   Paranaense University—Praça Mascarenhas de Moraes, Umuarama, Paraná, Brazil
,
Jessé Lahos Borges 
1   Paranaense University—Praça Mascarenhas de Moraes, Umuarama, Paraná, Brazil
,
Matheus Basilio Marçal 
1   Paranaense University—Praça Mascarenhas de Moraes, Umuarama, Paraná, Brazil
,
João Vitor Morais Simões 
1   Paranaense University—Praça Mascarenhas de Moraes, Umuarama, Paraná, Brazil
,
Selma Alves Rodrigues 
1   Paranaense University—Praça Mascarenhas de Moraes, Umuarama, Paraná, Brazil
,
Zilda Cristiani Gazim 
1   Paranaense University—Praça Mascarenhas de Moraes, Umuarama, Paraná, Brazil
,
Ranulfo Piau Júnior 
1   Paranaense University—Praça Mascarenhas de Moraes, Umuarama, Paraná, Brazil
› Author Affiliations Funding This research was supported by Paranaense University. The authors thank the Minerphós Company for kind donation of the products.
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Abstract

Background Bovine mastitis is characterized by an inflammatory process in the mammary gland and represents one of the main diseases affecting a dairy herd. Management of mastitis is most commonly via antibiotics, but the rising incidence of multiple antibiotic resistance (MAR) means that additional options are needed. Homeopathic products can be administered in dairy farming for a range of clinical reasons and may be preferential due to the absence of residues.

Objectives The aim of this study was to assess the potential of a novel homeopathic complex medicine in managing bovine mastitis.

Methods Twenty-four lactating Holstein cows with mastitis were divided into two groups: the homeopathic complex group received a homeopathic complex daily for 60 days at a dose of 20 g/d; the placebo group received the calcium carbonate vehicle without homeopathic medicines at the same dose and repetition. The main outcome measure was somatic cell count (SCC; cells/mL), with additional outcome measures including milk production (kg/d), milk constituents (percentage of protein, fat, lactose and total milk solids), and serum levels of cortisol, glucose, ammonia and lactic acid. All outcomes were measured at the beginning of the study and after 30 and 60 days. Milk samples were also collected from all animals at the beginning of the study, confirming a high (>0.2) MAR index for isolated bacterial cultures.

Results Assessment of SCC showed a statistically significant difference favoring the homeopathic complex versus placebo group at day 60. A reduction in serum cortisol levels and an increase in fat, lactose and total milk solids in animals treated with the homeopathic complex at day 60 were also seen. Other outcome measures did not show statistically significant inter-group differences.

Conclusion The results of this non-randomized, open-label, placebo-controlled trial suggest the potential for a novel homeopathic complex medicine in management of multiple antibiotic-resistant bovine mastitis, thus offering dairy farmers an additional option to antibiotics and making dairy products safer for consumer health and milk production more sustainable.

Keywords

bovine mastitis - homeopathy - milk quality - somatic cell count - milk constituents

Supplementary Material



Publication History

Received: 21 July 2022

Accepted: 22 February 2023

Article published online:
05 July 2023

© 2023. Faculty of Homeopathy. This article is published by Thieme.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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