CC BY 4.0 · Indian J Med Paediatr Oncol
DOI: 10.1055/s-0043-1768049
Review Article

The Effects of Dietary Nutrient Intake on Cervical Cancer: A Brief Review

Suchismita Nath
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
Sultana S. Nasrin
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
Amrita Samanta
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
Anzum Nuzhad
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
Pritha Ghosh
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
Atanu Manna
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
Satyasundar Pradhan
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
Suresh Maity
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
Srikanta Pal
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
P.K. Das Mohapatra
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
Subhas Chandra Jana
1   Department of Microbiology, Raiganj University, Raiganj, Uttar Dinajpur, West Bengal, India
› Author Affiliations
Funding This research received funding from ICMR.


Cervical cancer (CC) results from a subsequent process, starting from the infection of normal cervical epithelium with oncogenic human papillomavirus and gradually progressing to cervical intraepithelial neoplasia (CIN), before finally developing into invasive cervical cancer (ICC). Over recent decades, dietary micronutrients have gained much attention due to their pivotal role in cancer prevention. We reviewed several relevant literature studies to investigate the protective roles of dietary nutrient intake in CC. Dietary intake of vitamin C, green–yellow vegetables, and provitamin A carotenoids that are rich sources of antioxidants may widely inhibit the process of CC development, whereas vitamins A and D might be more helpful in preventing the early events in the disease development. Vitamin E, lycopene, and folate are more effective for the treatment of high-grade CIN. Fruits exert their protective effects in the late stages of the cancer process, thus playing a vital role in ICC prevention. Polyphenols, flavonoids, and polyunsaturated fatty acids are more often used in cases of CC in combination with chemotherapy and radiotherapy. Thus, as a primary prevention strategy, the health benefits of various nutrients in CC must be clarified by vitro and in vivo approaches rather than epidemiological studies.


All the authors contributed in literature survey, collection of data, and manuscript writing.

Publication History

Article published online:
24 April 2023

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  • References

  • 1 McTiernan A, Irwin M, Vongruenigen V. Weight, physical activity, diet, and prognosis in breast and gynecologic cancers. J Clin Oncol 2010; 28 (26) 4074-4080
  • 2 Koshiyama M. The effects of the dietary and nutrient intake on gynecologic cancers. Healthcare 2019; 7 (03) 88
  • 3 Zhang X, Zeng Q, Cai W, Ruan W. Trends of cervical cancer at global, regional, and national level: data from the Global Burden of Disease study 2019. BMC Public Health 2021; 21 (01) 894
  • 4 Yang X, Da M, Zhang W, Qi Q, Zhang C, Han S. Role of Lactobacillus in cervical cancer. Cancer Manag Res 2018; 10: 1219-1229
  • 5 Sung H, Ferlay J, Siegel RL. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71 (03) 209-249
  • 6 Wideroff L, Potischman N, Glass AG. et al. A nested case-control study of dietary factors and the risk of incident cytological abnormalities of the cervix. Nutr Cancer 1998; 30 (02) 130-136
  • 7 Plummer M, Herrero R, Franceschi S. et al; IARC Multi-centre Cervical Cancer Study Group. Smoking and cervical cancer: pooled analysis of the IARC multi-centric case–control study. Cancer Causes Control 2003; 14 (09) 805-814
  • 8 Juneja A, Sehgal A, Mitra AB, Pandey A. A survey on risk factors associated with cervical cancer. Indian J Cancer 2003; 40 (01) 15-22
  • 9 Slattery ML, Robison LM, Schuman KL. et al. Cigarette smoking and exposure to passive smoke are risk factors for cervical cancer. JAMA 1989; 261 (11) 1593-1598
  • 10 Kim J, Kim MK, Lee JK. et al. Intakes of vitamin A, C, and E, and β-carotene are associated with risk of cervical cancer: a case-control study in Korea. Nutr Cancer 2010; 62 (02) 181-189
  • 11 Chih HJ, Lee AH, Colville L, Binns CW, Xu D. A review of dietary prevention of human papillomavirus-related infection of the cervix and cervical intraepithelial neoplasia. Nutr Cancer 2013; 65 (03) 317-328
  • 12 Wang H, Khor TO, Shu L. et al. Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem 2012; 12 (10) 1281-1305
  • 13 Mayne ST. Beta-carotene, carotenoids, and disease prevention in humans. FASEB J 1996; 10 (07) 690-701
  • 14 Palan PR, Romney SL, Mikhail M, Basu J, Vermund SH. Decreased plasma/3-carotene levels in women with uterine cervical dysplasias and cancer. J Natl Cancer Inst 1988; 80 (06) 454-455
  • 15 Zhang X, Dai B, Zhang B, Wang Z. Vitamin A and risk of cervical cancer: a meta-analysis. Gynecol Oncol 2012; 124 (02) 366-373
  • 16 Verreault R, Chu J, Mandelson M, Shy K. A case-control study of diet and invasive cervical cancer. Int J Cancer 1989; 43 (06) 1050-1054
  • 17 Zhang YY, Lu L, Abliz G, Mijit F. Serum carotenoid, retinol and tocopherol concentrations and risk of cervical cancer among Chinese women. Asian Pac J Cancer Prev 2015; 16 (07) 2981-2986
  • 18 Butterworth Jr CE, Hatch KD, Gore H, Mueller H, Krumdieck CL. Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives. Am J Clin Nutr 1982; 35 (01) 73-82
  • 19 Kwanbunjan K, Saengkar P, Cheeramakara C. et al. Low folate status as a risk factor for cervical dysplasia in Thai women. Nutr Res 2005; 25 (07) 641-654
  • 20 Hernandez BY, McDuffie K, Wilkens LR, Kamemoto L, Goodman MT. Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. Cancer Causes Control 2003; 14 (09) 859-870
  • 21 Wuryanti S, Andrijono A, Susworo S, Witjaksono F. The effect of high poly unsaturated fatty acid (PUFA) dietary supplementation on inflammatory status of patients with advanced cervical cancer on radiation treatment. Acta Med Indones 2015; 47 (01) 45-49
  • 22 Bruni L, Albero G, Serrano B. et al. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in the World. Summary Report 22 October 2021, Accessed March 15, 2023 at:
  • 23 Delam H, Izanloo S, Bazrafshan MR, Eidi A. Risk factors for cervical cancer: an epidemiological review. J Health Sci Surveillance Syst 2020; 8 (03) 105-109
  • 24 Rao AV, Rao LG. Carotenoids and human health. Pharmacol Res 2007; 55 (03) 207-216
  • 25 La Vecchia C, Decarli A, Fasoli M. et al. Dietary vitamin A and the risk of intraepithelial and invasive cervical neoplasia. Gynecol Oncol 1988; 30 (02) 187-195
  • 26 Barchitta M, Maugeri A, Quattrocchi A, Agrifoglio O, Scalisi A, Agodi A. The association of dietary patterns with high-risk human papillomavirus infection and cervical cancer: a cross-sectional study in Italy. Nutrients 2018; 10 (04) 469
  • 27 Hirose K, Hamajima N, Takezaki T. et al. Smoking and dietary risk factors for cervical cancer at different age group in Japan. J Epidemiol 1998; 8 (01) 6-14
  • 28 Yang P, Su C, Luo X. et al. Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src/ERK pathway. Cancer Lett 2018; 438: 76-85
  • 29 Brock KE, Berry G, Mock PA, MacLennan R, Truswell AS, Brinton LA. Nutrients in diet and plasma and risk of in situ cervical cancer. J Natl Cancer Inst 1988; 80 (08) 580-585
  • 30 Wylie-Rosett JA, Romney SL, Slagle NS. et al. Influence of vitamin A on cervical dysplasia and carcinoma in situ. Nutr Cancer 1984; 6 (01) 49-57
  • 31 Batieha AM, Armenian HK, Norkus EP, Morris JS, Spate VE, Comstock GW. Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case-control study. Cancer Epidemiol Biomarkers Prev 1993; 2 (04) 335-339
  • 32 Tomita LY, Longatto Filho A, Costa MC. et al; Brazilian Investigation into Nutrition and Cervical Cancer Prevention (BRINCA) Study Team. Diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income Brazilian women. Int J Cancer 2010; 126 (03) 703-714
  • 33 García-Closas R, Berenguer A, José Tormo M. et al. Dietary sources of vitamin C, vitamin E and specific carotenoids in Spain. Br J Nutr 2004; 91 (06) 1005-1011
  • 34 Cao D, Shen K, Li Z, Xu Y, Wu D. Association between vitamin C Intake and the risk of cervical neoplasia: A meta-analysis. Nutr Cancer 2016; 68 (01) 48-57
  • 35 Stefanska B, Salamé P, Bednarek A, Fabianowska-Majewska K. Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr 2012; 107 (06) 781-790
  • 36 Schulte-Uebbing C, Schlett S, Craiut I, Antal L, Olah H. Chronical cervical infections and dysplasia (CIN I, CIN II): Vaginal vitamin D (high dose) treatment: A new effective method?. Dermatoendocrinol 2014; 6 (01) e27791
  • 37 Özgü E, Yılmaz N, Başer E, Güngör T, Erkaya S, Yakut Hİ. Could 25-OH vitamin D deficiency be a reason for HPV infection persistence in cervical premalignant lesions?. J Exp Ther Oncol 2016; 11 (03) 177-180
  • 38 Ono A, Koshiyama M, Nakagawa M. et al. The preventive effect of dietary antioxidants on cervical cancer development. Medicina (Kaunas) 2020; 56 (11) 604
  • 39 Witthöft CM, Forssén K, Johannesson L, Jägerstad M. Folates-food sources, analyses, retention and bioavailability. Näringsforskning 1999; 43 (01) 138-146
  • 40 Palan PR, Chang CJ, Mikhail MS, Ho GY, Basu J, Romney SL. Plasma concentrations of micronutrients during a nine-month clinical trial of β-carotene in women with precursor cervical cancer lesions. Nutr Cancer 1998; 30 (01) 46-52
  • 41 Rampersaud GC, Bailey LB, Kauwell GP. Relationship of folate to colorectal and cervical cancer: review and recommendations for practitioners. J Am Diet Assoc 2002; 102 (09) 1273-1282
  • 42 Liu RH. Health-promoting components of fruits and vegetables in the diet. Adv Nutr 2013; 4 (03) 384S-392S
  • 43 González CA, Travier N, Luján-Barroso L. et al. Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study. Int J Cancer 2011; 129 (02) 449-459
  • 44 Giuliano AR, Siegel EM, Roe DJ. et al; Ludwig-McGill HPV Natural History Study. Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study. J Infect Dis 2003; 188 (10) 1508-1516
  • 45 Kedhari Sundaram M, Raina R, Afroze N. et al. Quercetin modulates signaling pathways and induces apoptosis in cervical cancer cells. Biosci Rep 2019; 39 (08) BSR20190720
  • 46 Sharma C, Sadrieh L, Priyani A, Ahmed M, Hassan AH, Hussain A. Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells. Cancer Epidemiol 2011; 35 (03) 272-278
  • 47 Singh M, Bhui K, Singh R, Shukla Y. RETRACTED: tea polyphenols enhance cisplatin chemosensitivity in cervical cancer cells via induction of apoptosis. Life Sci 2013; 93 (01) 7-16