CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2023; 33(03): 338-343
DOI: 10.1055/s-0043-1767786
Original Article

A Comparison of Machine Learning Models for Survival Prediction of Patients with Glioma Using Radiomic Features from MRI Scans

Madhumitha Manjunath*
1   Department of Biotechnology, People's Education Society University, Bangalore, Karnataka, India
1   Department of Biotechnology, People's Education Society University, Bangalore, Karnataka, India
Shreya Kiran*
1   Department of Biotechnology, People's Education Society University, Bangalore, Karnataka, India
1   Department of Biotechnology, People's Education Society University, Bangalore, Karnataka, India
› Author Affiliations
Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.


Background Glioma is a primary, malignant, highly aggressive brain tumor, with patients having an average life expectancy of 14 to 16 months after diagnosis. Magnetic resonance imaging (MRI) scans of these patients can be used to extract and analyze quantifiable features with potential clinical significance. We hypothesize that there is a correlation between radiomic features extracted from MRI scans and survival. Along with clinical data, the radiomic features could be used in survival prediction of patients, providing beneficial information for clinicians to design personalized treatment plans.

Methods In our study, we have utilized 3D Slicer for tumor segmentation and feature extraction and performed survival prediction of patients with glioma using four different machine learning models.

Results and Conclusion Among the models compared, we have achieved a maximum prediction accuracy of 64.4% using the k-nearest neighbors model, which was trained and tested on a combination of clinical data and radiomic features extracted from MRI images provided in the BraTS 2020 dataset.

Author Contributions

The idea was conceived by all the authors. S.K. and M.M. performed feature extraction using the 3D Slicer software. S.S. performed the data visualization, coding for the four machine learning models, and implementation of survival prediction using R programming. The manuscript was prepared by all the authors. J.C. supervised the study and also reviewed and finalized the manuscript.

* These authors have contributed equally to the work.

Publication History

Article published online:
28 April 2023

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