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Relationship between Initial Lactate Level with Mortality in Children with Sepsis and Septic Shock: A Comparison with the PRISM-3 Score
Objective Sepsis and septic shock are leading causes of mortality and morbidity in intensive care units. Our study aimed to compare the pediatric risk of mortality (PRISM-3) score, which is used for predicting mortality risk among critically ill patients in pediatric intensive care units, with laboratory parameters, particularly lactate parameters.
Methods This study included 38 patients aged 1 month to 18 years who were managed for sepsis and septic shock in a pediatric intensive care unit. Lactate, D-dimer, troponin T, and N-terminal prohormone of brain natriuretic peptide levels were measured at the 0th and 24th hours. The patients were divided into survivors and nonsurvivors and those with septic shock and those without.
Results There were a total of 38 patients with a median age of 12 months, of whom 17 (44.7%) were males and 21 (55.3%) were females. Six (15.8%) patients died within 7 days after the diagnosis. Nonsurvivors had significantly higher median values of PRISM-3 (p = 0.002), C-reactive protein (p = 0.046), and partial arterial carbon dioxide pressure (p = 0.041). PRISM-3 showed a good discriminatory power (area under the curve [AUROC] = 0.878; p < 0.0001) and baseline lactate level showed a moderate level of discriminatory power (AUROC = 0.734 p = 0.0254) for early mortality within 7 days.
Conclusion PRISM-3 and baseline lactate predict early mortality in children with sepsis and septic shock. We suggest that adding lactate, which is not included in the PRISM-3 score, to the score may increase the score's predictive ability for mortality. We believe, however, that randomized, controlled, multicenter studies with larger sample sizes should be conducted to test this hypothesis.
G.B. and M.A. were responsible for study conception and design. Data collection was done by G.B., M.A., and H.S. Analysis and interpretation of results were done by G.B. and M.A. Draft manuscript preparation was done by G.B., M.A., and H.S. All the authors reviewed the results and approved the final version of the manuscript.
This study was approved by Kayseri City Hospital Clinical Research Ethics Committee (April/2020; No. 50).
Consent for Publication
This manuscript is not under simultaneous consideration by any other publication. All authors have approved the final manuscript and take full responsibility for the manuscript.
Received: 21 November 2022
Accepted: 26 January 2023
Article published online:
30 March 2023
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