A Systematic Review of Vestibular Evoked Myogenic Potential in Individuals with Motion Sickness

Abstract

The otolith of vestibular system in the human body helps in maintaining the static balance. Travelling can cause defect in static balance that may lead to motion sickness. The evidence showing the relation between vestibular evoked myogenic potential (VEMP) that assesses otolith function and motion sickness is contrasting. The current systematic review is aimed to understand outcomes of published articles in reporting association between vestibular evoked myogenic in individuals with motion sickness. For this study, the database used is PubMed, Scopus, ProQuest, CINHAL, and Web of Science. The data is extracted from the final articles where VEMP is done on individuals with and without motion sickness. The total articles included are 125 out of which five articles used for the systematic review. In this study, motion sickness susceptibility questionnaire is used to assess individuals with and without motion sickness. The latency and amplitude of both cervical VEMP (cVEMP) and ocular (oVEMP) of individuals with and without motion sickness are normal. However, the review indicates a significant change in the interaural asymmetry ratio of both cVEMP and oVEMP results in individuals with motion sickness. This shows that there might be a variation in the functional asymmetry in the otoliths. From the review, it is clear that there might be otolith changes due to motion sickness that can have a smaller impact on the interaural asymmetry ratio in VEMP. These findings can be further applied for the diagnostic purpose in individuals with motion sickness.

Keywords

cervical vestibular evoked myogenic potentials - motion sickness - ocular vestibular evoked myogenic potentials - otolith organ

Publication History

Article published online:
25 May 2023

• References

• 1 Khan S, Chang R. Anatomy of the vestibular system: a review. NeuroRehabilitation 2013; 32 (03) 437-443
• 2 Illich Zabolotnyi D, Serhiivna Mishchanchuk N, Vestibular system: anatomy, physiology, and clinical evaluation. In: Somatosensory and Motor Research. IntechOpen; 2020 doi:10.5772/intechopen.90538
• 3 Treisman M. Motion sickness: an evolutionary hypothesis. Science 1977; 197 (4302) 493-495
• 4 Dennison M, D’Zmura M. Effects of unexpected visual motion on postural sway and motion sickness. Appl Ergon 2018; 71: 9-16
• 5 Stoffregen TA, Draper MH, Kennedy RS, Compton D, Stanney KM. ed. Handbook of Virtual Environments: Design, Implementation, and Applications. Lawrence Erlbaum Associates; 2002: 773-790
• 6 Aust G, Hordinsky JR, Schmelzer B. Male and female characteristics in vestibular testing: a step toward the selection of the best participants for space flight. Acta Astronaut 1980; 7 (11) 1323-1331
• 7 Stoffregen TA, Draper MH, Kennedy RS, Compton D, Stanney KM. ed. Handbook of Virtual Environments: Design, Implementation, and Applications. Lawrence Erlbaum Associates; 2002: 773-790
• 8 Tal D, Gilbey P, Bar R, Shupak A. Seasickness pathogenesis and the otolithic organs: vestibular evoked myogenic potentials study—preliminary results. Isr Med Assoc J 2007; 9 (09) 641-644
• 9 Tal D, Hershkovitz D, Kaminski-Graif G, Wiener G, Samuel O, Shupak A. Vestibular evoked myogenic potentials and habituation to seasickness. Clin Neurophysiol 2013; 124 (12) 2445-2449
• 10 Kniep R, Zahn D, Wulfes J, Walther LE. The sense of balance in humans: Structural features of otoconia and their response to linear acceleration. PLoS One 2017; 12 (04) e0175769
• 11 Parker DE. The relative roles of the otolith organs and semicircular canals in producing space motion sickness. J Vestib Res 1998; 8 (01) 57-59
• 12 Boldingh MI, Ljøstad U, Mygland A, Monstad P. Vestibular sensitivity in vestibular migraine: VEMPs and motion sickness susceptibility. Cephalalgia 2011; 31 (11) 1211-1219
• 13 Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 1998; 52 (06) 377-384
• 14 Buyuklu F, Tarhan E, Ozluoglu L. Vestibular functions in motion sickness susceptible individuals. Eur Arch Otorhinolaryngol 2009; 266 (09) 1365-1371
• 15 Fowler CG, Sweet A, Steffel E. Effects of motion sickness severity on the vestibular-evoked myogenic potentials. J Am Acad Audiol 2014; 25: 814-822
• 16 Xie SJ, Chen W, Jia HB, Wang ZJ, Yao Q, Jiang YY. Ocular vestibular evoked myogenic potentials and motion sickness susceptibility. Aviat Space Environ Med 2012; 83 (01) 14-18
• 17 Singh NK, Pandey P, Mahesh S. Assessment of otolith function using cervical and ocular vestibular evoked myogenic potentials in individuals with motion sickness. Ergonomics 2014; 57 (12) 1907-1918
• 18 Neupane AK, Gururaj K, Sinha SK. Higher asymmetry ratio and refixation saccades in individuals with motion sickness. J Am Acad Audiol 2018; 29 (02) 175-186