CC BY-NC-ND 4.0 · Asian J Neurosurg 2023; 18(01): 216-218
DOI: 10.1055/s-0043-1764117
Case Report

A Rare Patient with Hereditary Spastic Paraparesis with Parkinsonism

1   Neurology Clinic, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
,
Selcuk Comoglu
1   Neurology Clinic, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey
› Institutsangaben

Abstract

Herein, we present a rare patient with hereditary spastic paraparesis (HSP) in whom significant parkinsonism was involved in the clinic. Besides, the dopamine transport single-photon emission computed tomography scan also showed decreased tracer uptake in the bilateral striatum. Via the presentation of this patient, we discuss the parkinsonian findings in patients with HSP. We think that the observations of dopaminergic neuron vulnerability in HSP patients raise the possibility that degeneration of central dopaminergic neurons may contribute to the phenotype of HSP. The documentation of these rare variants will aid to understand the unknown pathophysiology of the disease course.

Supplementary Material



Publikationsverlauf

Artikel online veröffentlicht:
03. April 2023

© 2023. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Shribman S, Reid E, Crosby AH, Houlden H, Warner TT. Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches. Lancet Neurol 2019; 18 (12) 1136-1146
  • 2 Seidel K, De Vos R, Derksen L. et al. Widespread thalamic and cerebellar degeneration in a patient with a complicated hereditary spastic paraplegia (HSP). Ann Anat 2009; 191 (02) 203-211
  • 3 De la Casa-Fages B, Fernández-Eulate G, Gamez J. et al. Parkinsonism and spastic paraplegia type 7: expanding the spectrum of mitochondrial Parkinsonism. Mov Disord 2019; 34 (10) 1547-1561
  • 4 Tranchant C, Koob M, Anheim M. Parkinsonian-pyramidal syndromes: a systematic review. Parkinsonism Relat Disord 2017; 39: 4-16
  • 5 Kim JS, Kim JM, Kim YK, Kim SE, Yun JY, Jeon BS. Striatal dopaminergic functioning in patients with sporadic and hereditary spastic paraplegias with parkinsonism. J Korean Med Sci 2013; 28 (11) 1661-1666
  • 6 Lee Y, Paik D, Bang S. et al. Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila. Neurobiol Aging 2008; 29 (01) 84-94
  • 7 Scarduzio M, Hess EJ, Standaert DG, Eskow Jaunarajs KL. Striatal synaptic dysfunction in dystonia and levodopa-induced dyskinesia. Neurobiol Dis 2022; 166: 105650