CC BY-NC-ND 4.0 · Asian J Neurosurg 2023; 18(01): 191-195
DOI: 10.1055/s-0043-1763525
Case Report

Intraparenchymal Schwannoma of Temporal Lobe: A Case Report and Review of the Literature

Sajjad Saghebdoust
1   Department of Neurosurgery, Razavi Hospital, Mashhad, Iran
Mohammad Amin Habibi
2   Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran
Mehran Ekrami
3   Department of Neurosurgery, Faculty of Medicine, Mashhad University of Mashhad, Mashhad, Iran
Farshid Khadivar
4   Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
1   Department of Neurosurgery, Razavi Hospital, Mashhad, Iran
Reza Zare
1   Department of Neurosurgery, Razavi Hospital, Mashhad, Iran
› Author Affiliations


Intracranial schwannomas (ISs) account for approximately 8% of intracranial tumors, while IS, a rare entity, is responsible for roughly 1% of IS. A 33-year-old man with a 3-month headache and sudden onset seizure was referred to our clinic. Preoperative magnetic resonance imaging revealed a contrast-enhancing mass accompanied by cystic components in the right temporal lobe. Ganglioglioma, metastasis, or glioblastoma multiforme was suspected, and surgery was advised. During surgery, gross total resection of a noninvasive tumor was conducted. Postoperative recovery was uneventful. Based on histopathological examination and confirmatory immunohistochemistry, the intraparenchymal temporal tumor was diagnosed as schwannoma. ISs are extremely scarce brain tumors mainly located on the surface of the brain or adjacent brain ventricles. The definite preoperative diagnosis of schwannoma cannot be readily established due to radiologically indistinguishable features from metastasis and gliomas; however, histopathology and immunohistochemistry are of great assistance. Complete surgical removal is the most preferred treatment alternative with a long-term favorable prognosis without adjuvant and neoadjuvant chemotherapy requirements.

Informed Consent

Written informed consent was obtained from the patient for the publication of this case report and accompanying images.

Authors' Contributions

S.S. and M.A.H. contributed to writing the paper, data collection, interpretation, and leadership responsibility for the research activity planning and execution, including mentorship external to the core team. M.E., F.K., and M.M.V. contributed to data collection and interpretation. R.Z. contributed to the study concept or design and interpretation.

Publication History

Article published online:
03 April 2023

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  • References

  • 1 Bhatheja K, Field J. Schwann cells: origins and role in axonal maintenance and regeneration. Int J Biochem Cell Biol 2006; 38 (12) 1995-1999
  • 2 Propp JM, McCarthy BJ, Davis FG, Preston-Martin S. Descriptive epidemiology of vestibular schwannomas. Neuro-oncol 2006; 8 (01) 1-11
  • 3 Deora H, Srinivas D, Beniwal M, Vikas V, Rao KVLN, Somanna S. Rare cranial nerve schwannomas: a retrospective review of nontrigeminal, nonvestibular cranial nerve schwannomas. J Neurosci Rural Pract 2018; 9 (02) 258-263
  • 4 McLendon R, Rosenblum M, Bigner D. Russell & Rubinstein's Pathology of Tumors of the Nervous System. 7th ed. London: CRC Press; 2006
  • 5 Casadei GP, Komori T, Scheithauer BW, Miller GM, Parisi JE, Kelly PJ. Intracranial parenchymal schwannoma. A clinicopathological and neuroimaging study of nine cases. J Neurosurg 1993; 79 (02) 217-222
  • 6 Guha D, Kiehl T-R, Krings T, Valiante TA. Intracerebral schwannoma presenting as classic temporal lobe epilepsy. J Neurosurg 2012; 117 (01) 136-140
  • 7 Paredes I, Jimenez Roldán L, Ramos A, Lobato RD, Ricoy JR. Intraparenchymal schwannomas: report of two new cases studied with MRI and review of the literature. Clin Neurol Neurosurg 2012; 114 (01) 42-46
  • 8 Kovalainen A, Haeren R, Paetau A, Lehecka M. Brainstem intraparenchymal schwannoma: a case report and literature review. Surg Neurol Int 2021; 12: 508
  • 9 Ten H, Adachi K, Yamaguchi F, Matsuno A, Teramoto A, Morita A. Occipital lobe epilepsy was presented in a patient with intracerebral schwannoma: a case report and literature review. Int J Neurosci 2019; 129 (03) 308-312
  • 10 Gao Y, Qin Z, Li D. et al. Intracerebral schwannoma: a case report and literature review. Oncol Lett 2018; 16 (02) 2501-2510
  • 11 Sharma MC, Karak AK, Gaikwad SB, Mahapatra AK, Mehta VS, Sudha K. Intracranial intraparenchymal schwannomas: a series of eight cases. J Neurol Neurosurg Psychiatry 1996; 60 (02) 200-203
  • 12 Lipper MH, Eberhard DA, Phillips CD, Vezina L-G, Cail WS. Pleomorphic xanthoastrocytoma, a distinctive astroglial tumor: neuroradiologic and pathologic features. AJNR Am J Neuroradiol 1993; 14 (06) 1397-1404
  • 13 Zagardo MT, Castellani RJ, Rees JH, Rothman MI, Zoarski GH. Radiologic and pathologic findings of intracerebral schwannoma. AJNR Am J Neuroradiol 1998; 19 (07) 1290-1293
  • 14 Bruner J. Immunocytochemistry of recurring intracerebral nerve sheath tumor. J Neuropathol Exp Neurol 1984; 43: 296
  • 15 Rodriguez-Salazar A, Carrillo R, de Miguel J. Intracerebral schwannoma in a child: report of a case. Childs Brain 1984; 11 (01) 69-72