IntrAarticular Injections for Osteoarthritis (OA)

Introduction: Intra-articular knee injections are reserved for patients with medication-refractory moderate-to-severe knee osteoarthritis (OA) or during acute OA flares. This educational exhibit will review indications, evidence, and recommendations of different intra-articular treatment options for knee OA.

Method(s): The methods used in this educational abstract include: a discussion of indications for intra-articular treatment for knee osteoarthritis (OA), a discussion of current intra-articular injectable options, a review of current literature regarding the efficacy of the different intra-articular treatment options, and a review of current professional society guidelines on intra-articular treatment options.

Result(s): Corticosteroids intra-articular injections are common and work by reducing inflammation. Hyaluronic acid injections normalize synovial fluid viscoelasticity. Other intra-articular therapies include platelet-rich-plasma and autologous conditioned serum, mesenchymal stem cells, and prolotherapy.

Conclusion(s): According to professional society guidelines based on varying levels of evidence, corticosteroid injections, followed by hyaluronic injections, can be considered for intra-articular OA therapies.

Publication History

Article published online:
09 February 2023