Cryoablation in Desmoid Tumors

Introduction: Our objective is to determine the efficacy and safety of cryoablation in patients unresectable with desmoid tumors which was progressed on chemotherapy retrospectively at a single institution for the period of 1 year.

Method(s): This is a retrospective, single-institution review identified 10 patients (age: 4–45) with extra-abdominal desmoid tumors who received CT-guided percutaneous cryoablation salvage treatment in total 14 sessions in the year. Median maximal lesion diameter was 6 cm; intent was palliative in all patients. Contrast-enhanced cross-sectional imaging was obtained before and after treatment in addition to routine clinical follow-up.

Result(s): Technical success was achieved in all patients. The median follow-up was 5 months. Symptomatic improvement was demonstrated in 85% of patients. At 3 months, the average change in viable volume was −75% and mRECIST was PR 70%, and SD 30% .No rapid postablation growth or track seeding was observed.

Conclusion(s): Cryoablation for desmoid tumors demonstrates a high degree of symptom improvement and local tumor control on early follow-up imaging with relatively low morbidity.

Publication History

Article published online:
09 February 2023