ICAD Is Associated with Worse Outcomes in Acute Large Vessel Occlusion after Thrombectomy

Introduction: Acute large vessel occlusion (LVO) can be secondary to thromboembolism or intracranial atherosclerotic disease (ICAD). Data on LVO management due to underlying ICAD are scarce.

Method(s): We performed a retrospective analysis of consecutive patients who underwent MT for LVO in a large academic comprehensive stroke center between January 14, 2018 and October 24, 2021. We compared in-hospital mortality, 90-day mortality, and 90-day modified Rankin Scale (mRS) scores between those with and without ICAD, in unadjusted and adjusting logistic regression models.

Result(s): After adjusting for prognostic variables, ICAD was independently associated with in-hospital mortality (OR = 4.1, 95% CI 1.7–9.7), 90-day mortality (OR = 3.7, 95% CI 1.6–8.6), and poor functional outcome at 90 days (OR = 5.5, 95% CI 1.6–19.4).

Conclusion(s): Symptomatic ICAD in a predominantly African American cohort is associated with increased odds of mortality and poor functional outcome after MT.

Publication History

Article published online:
09 February 2023