Hypercoagulable States: A Vascular Interventional Radiology Perspective

Introduction: A hypercoagulable state is an increased susceptibility to developing thrombosis due to genetic or acquired factors. As no single test can isolate thrombophilia, an algorithmic approach is utilized. The presence of thrombophilia can alter the risk of a procedure and postoperative management.

Method(s): In this exhibit, we begin by discussing the various modes through which hypercoagulable states arise, including hereditary and acquired causes. Next, we elucidate the algorithmic approach highlighting when and how laboratory screening panels are utilized to isolate hypercoagulable states. Lastly, we will briefly discuss the changes in the postoperative medical management of VTEs in the setting of various thrombophilias.

Result(s): Hypercoagulable states include genetic and acquired causes. Screening panels for thrombophilia include bleeding time, PTT, PT, functional assays, antibody assays, genetic assays, and mixing studies. A thrombophilia can alter postoperative management including thromboprophylaxis or anticoagulation.

Conclusion(s): Understanding hypercoagulable states, including their algorithmic workup and role in the postoperative management of VTEs, is an essential topic for the vascular and interventional radiologist.

Publication History

Article published online:
09 February 2023