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CC BY 4.0 · Chinese medicine and natural products 2023; 03(01): e15-e28
DOI: 10.1055/s-0043-1762571
Review Article

Meta-analysis and Construction of Core Indicator Field of Pediatric Bronchitis Treated by Chinese Herbs Acupoint Application Therapy

Zhenzhen Qian
1   Postdoctoral Research Station, China Academy of Chinese Medical Sciences, Beijing, China
2   Institute of Basic Clinical Medicine of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China
,
Rui Li
3   The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China
,
Juan Duan
4   China Academy of Chinese Medical Sciences, Guang'anmen Hospital, Beijing, China
,
Zhiwei Jing
2   Institute of Basic Clinical Medicine of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China
,
Rui Gao
5   Institute of Clinical Pharmacology, China Academy of Chinese Medical Sciences, Beijing, China
› Author Affiliations Funding This work was supported by the General Project of the National Natural Science Foundation of China (82074584) National Chinese Medicine Innovative Key Professionals Improvement Program ([2019] No.128)
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Abstract

Objective Our objective was to explore the commonly used herbs, acupoints, and efficacy evaluation indicators of Chinese herbs acupoint application therapy in the treatment of pediatric bronchitis, screen and construct the core index field, and systematically evaluate the efficacy and safety of Chinese herbs acupoint application therapy in the treatment of this disease.

Methods Chinese periodical databases such as China National Knowledge Infrastructure, Wanfang database, VIP Information, and Chinese Biomedical Literature database were searched, and the literature information was extracted manually to establish data tables for data analysis and the key efficacy evaluation index field. The quality of the included studies was assessed using the Cochrane Systematic Bias Risk Assessment Tool and the relevant efficacy indicators were meta-analyzed using RevMan 5.3 software.

Results The most commonly used herbs in acupoint application therapy were wind-cold dispersing herbs and cough-asthma relieving herbs. Feishu (BL 13), Danzhong (RN 17), and Tiantu (RN 22) were the main acupoints. The core indicators were effective rate, improvement of main symptoms/signs, onset time, disappearance time, traditional Chinese medicine (TCM) syndrome score, and symptom score. Meta-analysis results showed that the total effective rate was 0.11 (0.08, 0.33) (Z = 8.64, p < 0.00001), I 2 = 39%; due to the heterogeneity of cough, expectoration, asthma, and other indicators, the meta-analysis was abandoned.

Conclusion In terms of total efficiency, Chinese medicine acupoint application therapy is superior to conventional Western medicine in efficacy and shortening the time of symptoms of pediatric asthmatic bronchitis. However, as the quality of the evidence included in the study is medium and low, and in the selection of indicators, there are more composite and relatively subjective indicators such as total effective rate, TCM syndrome score, and symptom score. Therefore, it is necessary to further standardize the efficacy indicators in this field and carry out high-quality and detailed Chinese medicine clinical randomized controlled trials.

Keywords

pediatric bronchitis - acupoint application therapy - data mining - core indicators - systematic review - meta-analysis

CRediT Authorship Contribution Statement

Z.Q. was responsible for conceptualization, data curation, formal analysis, investigation, methodology, visualization, writing—original draft. R.L. and J.D. were responsible for methodology, writing—review and editing. Z.J. was responsible for funding acquisition, supervision, writing—review and editing. R.G. was responsible for project administration, resources, and writing—review and editing.




Publication History

Received: 12 October 2022

Accepted: 27 December 2022

Article published online:
06 March 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
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